- Conditional knockout (cKO) mice can be used to study specific gene function and related human
diseases. Compared to conventional knockout (KO) mice, genes obtained in conditional knockout mice are deleted
only in specific tissues or in inducible situations.
Compared to constitutively expressed gene mutations,
conditional KO models provide more space for
regulation of the time and region of gene expression. Therefore, this model is a more accurate model for
studying human diseases.
- We create conditional knockout(cKO) mice using a novel strategy namely the short condtional intron(SCON)
- knock-in(KI) can insert a specific mutation or foreign gene into the target gene location. For example, by introducing a point mutation (simulating a human genetic disease model) into the target gene or introducing a reporter gene into a specific region of the target gene through homologous recombination.
IBS Center for Genome Engineering,55 EXPO-ro, Doryong-dong, Yuseong-gu, Daejeon (34126)
042-878-8317
