Contact: jeakwon@ibs.re.kr (official) onlytojay@gmail.com (private)
Pubmed: https://www.ncbi.nlm.nih.gov/
Github: https://github.com/jeakwon/
EDUCATION
[2007.03 ~ 2012.03] Full Scholarship Korea - Japan Joint Government Program
[2008.04 ~ 2012.03] B.E. in Electrical and Electronic Systems at Saitama University, Japan
[2013.08 ~ present] Ph.D. course, KU-KIST Graduate School of Converging Science and Technology in Korea University
[2014.03 ~ 2018.11] Researcher, Center for Functional Connectomics, Korea Institute of Science and Technology (KIST), Republic of Korea
[2017.03 ~ present] Technical Research Personnel (Mandatory military service in Republic of Korea)
[2018.12 ~ present] Researcher, Center for Cognition and Sociality, Institute for Basic Science (IBS), Republic of Korea
INTERESTS
- Astrocyte-Neuron Interaction
- Circadian Rhythm and Sleep
- Synaptic Plasticity
- Cognition, Human intelligence
- Brain-inspired Artificial Intelligence
Skills
- Live cell/slice electrophysiology
- Live cell/slice imaging
- EEG/Circadian rhythm recording
- Python/Matlab programing for data analysis (imaging, electrophysiology, behavior)
- Python programing for machine learning
PUBLICATIONS
Ultrasonic Neuromodulation via Astrocytic TRPA1. Oh SJ, Lee JM, Kim HB, Lee J, Han S, Bae JY, Hong GS, Koh W, Kwon J, Hwang ES, Woo DH, Youn I, Cho IJ, Bae YC, Lee S, Shim JW, Park JH, Lee CJ. Curr Biol. 2019 Oct 21;29(20):3386-3401.e8. doi: 10.1016/j.cub.2019.08.021. Epub 2019 Oct 3.
Tweety-homolog (Ttyh) Family Encodes the Pore-forming Subunits of the Swelling-dependent Volume-regulated Anion Channel (VRACswell) in the Brain. Han YE, Kwon J, Won J, An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung JY, Park H, Oh SJ, Lee CJ. Exp Neurobiol. 2019 Apr;28(2):183-215. doi: 10.5607/en.2019.28.2.183. Epub 2019 Apr 30.
Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum. Woo J, Min JO, Kang DS, Kim YS, Jung GH, Park HJ, Kim S, An H, Kwon J, Kim J, Shim I, Kim HG, Lee CJ, Yoon BE. Proc Natl Acad Sci U S A. 2018 May 8;115(19):5004-5009. doi: 10.1073/pnas.1721187115. Epub 2018 Apr 24.
Development of a Low-cost, Comprehensive Recording System for Circadian Rhythm Behavior. Kwon J, Park MG, Lee SE, Lee CJ. Exp Neurobiol. 2018 Feb;27(1):65-75. doi: 10.5607/en.2018.27.1.65. Epub 2018 Feb 28.
Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes. Kwon J, An H, Sa M, Won J, Shin JI, Lee CJ. Exp Neurobiol. 2017 Feb;26(1):42-54. doi: 10.5607/en.2017.26.1.42. Epub 2017 Feb 9.
The Ca2+-activated chloride channel anoctamin-2 mediates spike-frequency adaptation and regulates sensory transmission in thalamocortical neurons. Ha GE, Lee J, Kwak H, Song K, Kwon J, Jung SY, Hong J, Chang GE, Hwang EM, Shin HS, Lee CJ, Cheong E. Nat Commun. 2016 Dec 19;7:13791. doi: 10.1038/ncomms13791.
EDUCATION
MAR 2014~ present Ph.D. course, KU-KIST Graduate
School of Converging Science and Technology, Seoul, Korea (Thesis advisor: Dr. Changjoon Justin Lee)
MAR 2006~ FEB 2011 B.A. College of Life science &
Biotechnology, Korea University, Seoul, Korea
RESEARCH
EXPERIENCE
NOV 2018~ Present Researcher, Center for
Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, Korea
FEB 2014~ NOV 2018 Researcher, Center for
Functional Connectomics, Korea Institute of Science and Technology (KIST),
Seoul, Korea
RESEARCH
INTERSTS
Neuron-glia
interaction
Reactive
astrocytes in hypothalamus, Obesity and metabolism
Learning
and memory, ADHD
EXPERIMENTAL
TECHNIQUES
Slice
patch recording (Neuron), Cell patch (COS-7, HEK293T), Ca2+ Imaging
Confocal
microscope imaging, Immunohistochemistry, Immunocytochemistry
Primary
astrocyte culture, PCR, RT-PCR, DNA/RNA prep., Cloning
Stereotaxic
surgery, Open field test, Elevate plus maze, Passive avoidance test, Eight arm
radial maze
AWARDS
AUG 2018 BEST PRESENTATION AWARD at 21st KSBNS Annual Meeting
(Poster title: GABA from Reactive
Astrocytes in Hypothalamus via Monoamine Oxidase B Causes and Exacerbates
Obesity)
NOV 2016 Second
Award at KIST-BSI Conference 2016
(Poster
title: GABA
from Reactive Astrocytes may Cause and Exacerbate Obesity)
SEP 2016 Second Award at 2016
Converging Conference for KIST-School Ties
(Poster
title: GABA
from Reactive Astrocytes may Cause and Exacerbate Obesity)
PUBLICATION
1. NaHye Lee*, Moonsun Sa*, Yu Ri Hong, C. Justin
Lee†, and JaeHyung Koo†. Fatty Acid Increases cAMP-dependent Lactate and
MAO-B-dependent GABA Production in Mouse Astrocytes by Activating a Gαs
Protein-coupled Receptor. Experimental Neurobiology, 2018
Oct;27(5):365-376. doi: 10.5607/en.2018.27.5.365.
2. Jea Kwon, Heeyoung An, Moonsun Sa, Joungha Won,
Jeong Im Shin, and C. Justin Lee. Orai1 and Orai3 in combination with stim1
mediate the majority of store-operated calcium entry in astrocytes. Experimental
Neurobiology, 2017 Feb;26(1):42-54. doi: 10.5607/en.2017.26.1.42.
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EDUCATION
- 2007.03 ~ 2014.02 : B.A. in Yonsei
University
- 2016.03 ~ Present : Ph.D Course (KU-KIST,
Advisor: C. Justin Lee)
RESEARCH EXPERIENCES
- 2012.07 ~ 2013.06 Undergraduate Intern
(Prof. Park in Yonsei University, Immunology)
- 2014.03 ~ 2014.08 Undergraduate Intern
(Prof. Lee in Yonsei University, Bioinformatics)
- 2014.10 ~ 2016.02 Internship (Dr. C.
Justin Lee's lab, Glioscience)
PUBLICATIONS
- Yong Kyoung Yoo, Jaekwang Lee, Jinsik
Kim, Gangeun Kim, Sunpil Kim,
Jeongyeon Kim, Heejung Chun, Jeong Hoon Lee, C. Justin Lee & Kyo Seon
Hwang, Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in
the brain of freely moving mice using an interdigitated microelectrode (IME)
biosensor, Scientific Reports, 2016.
EXPERIMENTAL TECHNIQUES
- Imaging:
Acute brain slice imaging (Calcium, Fura-2 and various sensors)
2-photon brain slice imaging
- Behavior:
Social behaviors (3-chamber test and five-trial social memory test)
General behaviors (Open field test, novel object recognition and novel
place recognition test)
Fear-associated behavior (Passive avoidance test and contextual fear
conditioning)
- Electrophysiology:
Patch clamping (Cultured cell and acute brain slice)
- Molecular biology:
Cloning, RT-PCR and Western blot
- Primary astrocyte culture and
microporation
- Stereotaxic surgery :
Guide cannulation (Microdialysis)
Virus injection
- Immunohistochemistry (IHC) for mouse
- Microdialysis
AWARDS
- Outstanding presentation award (2018 5th
SGFP Annual Conference)