Dr. Park earned his B.A. in Biology from Sogang University and his Ph.D. in Physiology from Seoul Nat'l University. Before accepting a job offer from IBS, he had worked as an assistant professor in Dep of Physiology, Jeju Nat'l University School of Medicine and a research associate in The Solomon H. Snyder Dep of Neuroscience, Johns Hopkins School of Medicine. Throughout his research career, he has illuminated the pathological mechanisms of excitatory synaptic transmission through analysis of Arc/Arg3.1, EF2K, and Homer1a in autism and chronic neural impairment through the electrophysiological analysis. The findings have been reported in five papers in high-profile journals such as Cell, Nature Neuroscience and Neuron. His research interest centers upon the development of new non-invasive neuromodulation techniques for clinical translation and the mechanisms of synaptic dysfunction in neuropsychiatric disorders. (Cognitive Glioscience Group | Major/Faculty | IBS Campus, UST)
Research Interests : Neural plasticity, Learning & memory, Non-invasive neuromodulation technique development, Neuropsychiatric diseases (Schizophrenia, Parkinson disease)
Undergraduate:
Sogang Univ. Korea
B.A in Biology, August 1997
Graduate:
Seoul National Univ. College of Medicine, Korea
Department of Physiology
PhD, February 2004
MS. February 2000
Post Doctoral:
Dept. of Neuroscience, Johns Hopkins Univ. School of Medicine, USA
Research Associate | 2009-2012 Dept. of Neuroscience, Johns Hopkins Univ. School of Medicine, USA |
Assistant Professor | 2012-2015 Dept. of Neuroscience, Johns Hopkins Univ. School of Medicine, USA |
The distinguished scientist support program funded by Jeju Nat’l Univ (2014).
1. Lin et al., (2020) Persistently elevated mTOR complex1-S6K kinase 1 disrupts DARPP-32-dependent D1 dopamine receptor signaling and behaviors. Biological Psychiatry 3223(20) 32031-32027
2. Kim et al., (2019) Histone demethylase PHF2 activates CREB and promotes memory consolidation. EMBP Rep e45907
3. Kim et al., (2019) Association of mGluR-dependent LTD of excitatory synapses with endocannabinoid-dependent LTD of inhibitory synapses leads to EPSP to spike potentiation in Ca1 pyramidal neurons. Journal of Neuroscience 39(2) 224-237
4. Keum et al., (2018) A Missense Variant at the Nrxn3 Locus Enhances Empathy Fear in the Mouse. Neuron 98:588-601
5. Kim et al., (2016) Protein Arginine Methylation Facilitates KCNQ Channel-PIP2 Interaction Leading to Seizure Suppression. eLife 2016;5:217159
6. Shim et al., (2016) mGluR1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol 115:2446-2455
7. Park et al., (2013) A Prolyl-isomerase Mediates Dopamine-dependent Plasticity and Cocaine Motor Sensitization. Cell 154(3):637-650
8. Hu and Park et al., (2010) Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron 68:1128-1142
9. Park et al., (2008) Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. Neuron 59(1): 70-83
10. Cho et al., (2008) mGluR1/5-dependent long-term depression requires the regulated ectodomain cleavage of neuronal pentraxin NPR by TACE. Neuron 57(6):858-871
PhD Student
thuytienphan0604@gmail.com
PhD Student
r.previn2903@yahoo.com