Research Assistant | |
monsterktk@gmail.com | |
From 2011.04 to 2012.08 | |
Currently at Max Planck Florida Institute | |
Currently at MIT (Ph.D. Course) |
Tai Young Kim
Cholesteol metablisim in glioblastoma, Indentification of interacting proteins using BioID, Drug development against COVID-19 coronavirus (SARS-CoV-2)
EDUCATION
2002 Ph.D.
in Tumor Biology, Seoul National University, College of Medicine, Korea (advisor:
Yung-Jue Bang)
1996 M.S.
in Microbiology, Seoul National University, Korea (advisor: Gajin Jeong)
1993 B.S.
in Microbiology, Hankuk University of Foreign Studies, Korea.
PROFESSIONAL
EXPERIENCES
06/2020 – Current Senior Researcher, Center for Cognitive and Sociality, Institute for Basic Science, Daejeon, Korea
01/2019 –
05/2020 Research Fellow, Cognitive
Glioscience Group, Center for Cognitive and Sociality, Institute for Basic
Science, Daejeon,
Korea
11/2015 – 12/2018 Research Professor, Kyung Hee University
Korean Medicine, Korea.
01/2014 – 10/2015
Principal Research Scientist, Research Institute
of Pharmaceutical Sciences, College of Pharmacy, Seoul National
University,
Korea.
08/2013 – 12/2013
Research Associate Professor, School of
Nano-Bioscience and Chemical Engineering, UNIST, Republic of Korea
01/2009 - 07/2013
Postdoctoral Research Associate, Lineberger
Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
(Advisor:
Channing J. Der)
01/2004 - 12/2008 Postdoctoral Research Associate, Department of
Pharmacology, University of North Carolina, Chapel Hill, NC
(Advisor: Rudy L.
Juliano)
08/2002 - 12/2003 Postdoctoral Research Associate, Cancer
Research Institute, Seoul National University, Korea (advisor: Yung-Jue Bang)
07/1998 - 03/1999 M.S. Researcher, Cancer Research Institute,
Seoul National University, Korea
AWARDS and FELLOWSHIPS
2016-2019 Research Fellow Grant, Ministry of Education,
Korea of Republic
2013–2016 Research
Fellow Grant, Ministry of Education, Korea of Republic
2009-2011 Susan
G. Komen Research Grant
2003 Young
Researcher Awards in Seoul National University Cancer Research Institute
PUBLICATION
Jang MW, Oh D, Yi E, Liu X, Ling J, Kim N, Sharma K, Kim TY, Lee S, Kim AR, Kim MY, Kim MA, Lee M, Han JH, Han JJ, Park HR, Kim BJ, Lee SY, Woo DH, Oh J, Oh SJ, Du T, Koo JW, Oh SH, Shin HW, Seong MW, Lee KY, Kim UK, Shin JB, Sang S, Cai X, Mei L, He C, Blanton SH, Chen ZY, Chen H, Liu X, Nourbakhsh A, Huang Z, Kang KW, Park WY, Feng Y, Lee CJ, Choi BY (2021) A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder. Proc Natl Acad Sci, USA. Jun 1;118(22)
Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim ST, Lee CJ (2021) Platycodin D, a natural product from Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med, May;53(5):956-972
Lee SJ, Choi YJ, Kim HI, Moon HE, Baek SH, Kim TY, Ko SG (2021) LDLR facilitates platycodin D-induced autophagy inhibition.and cell death in glioblastoma cells. Mol Oncol. May 1 *Co-corresponding Author.
Kim HI, Lee SJ, Choi YJ, Kim MJ, Kim TY, Ko SG (2021) Quercetin induces apoptosis in glioblastoma cell lines U87MG and U373MG by suppressing Axl/IL-6/STAT3 signaling pathway. Am J Chin Med, Mar 3;1-18. *Co-corresponding Author
Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG. (2020) Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells. Sci Rep, Nov 16;10(1):1983. *Co-corresponding Author
Won J, Lee S, Park M, Kim TY, Park MG, Choi BY, Kim D, Chang H, Kim VN, Lee CJ (2020) Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19). Exp Neurobiol, Apr 30; 29(2):107-119.
Hong SH, Ku JM, Kim HI, Kim TY, Seo HS, Shin YC, Ko SG (2019) Topical Application of KAJD Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms Through Regulation of IgE and MAPK Pathways in BALB/C Mice and Several Immune Cell Types. Front Pharmacol. Sep 19; 10:1097.
Kim HI, Hong SH, Ku JM, Lim YS, Lee SJ, Song J, Kim TY, Cheon C, Ko SG. (2019) Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. Am J Chin Med. 47(3):691-705
Ku JM, Hong SH, Kim SR, Choi HS, Kim HI, Kim DU, Oh SM, Seo HS, Kim TY, c, Cheon C, Ko SG. (2018) Novel mechanism The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo. BMC Complement Altern Med. Jul 13;18(1):215
Kim HI, Hong SH, Ku JM, Kang S, Kim TY, Shin YC, Ko SG. (2017) Tonggyu-tang, a traditional Korean medicine, suppresses pro-inflammatory cytokine production through inhibition of MAPK and NF-κB activation in human mast cells and keratinocytes. BMC Complement Altern Med. Mar 31;17(1):186
Kim HJ, Kwon S, Nam SH, Jung JW, Kang M, Ryu J, Kim JE, Cheong JG, Cho CY, Kim S, Song DG, Kim YN, Kim TY, Jung MK, Lee KM, Pack CG, Lee JW. (2017) Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments.FASEB J. 2017, 31(4):1461-1481.
Choi J, Kang M, Nam SH, Lee GH, Kim HJ, Ryu J, Cheong JG, Jung JW, Kim TY, Lee HY, Lee JW (2015) Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors. Lung Cancer, 90(1):22-31
Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang MK, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, and Lee JW (2015) Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. Oncotarget, 6(25): 21655-74
Lee D, Na J, Ryu J, Kim HJ, Nam SH, Kang M, Jung JW, Lee MS, Song HE, Choi J, Lee GH, Kim TY, Chung JK, Park KH, Kim SH, Kim H, Seo H, Kim P, Youn H, Lee JW (2015) Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. Hepatology, 61(6):1978-97
Kim TY, Seisser PM, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss, M, Moon RT, Der CJ, Major MB (2015) Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase. Mol Cell Biol, 35(1):167-81
Kang M, Ryu J, Lee D, Lee MS, Kim HJ, Nam SH, Song HE, Choi J, Lee GH, Kim TY, Lee H, Kim SJ, Ye SK, Kim S, Lee JW (2014) Correlations between Transmembrane 4 L6 Family Member 5 (TM4SF5), CD151, and CD63 in Liver Fibrotic Phenotypes and Hepatic Migration and Invasive Capacities. PLoS One. 9(7):e102817
Lee MS, Kim S, Kim BG, Won C, Nam SH, Kang S, Kim HJ, Kang M, Ryu J, Song HE, Lee D, Ye SK, Jeon NL, Kim TY, Cho NH, Lee JW (2014) Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation. Biochim Biophys Acta. 1843(9):2037-54
Kim TY, Jackson S, Xiong Y, Whitsett TG, Lobello JR, Tran NL, Malek NP, Bang YJ, Der CJ (2013) Loss of DLC1 RhoGAP tumor suppressor expression and function by CUL4A-DDB1-FBXW5-dependent ubiquitination and degradation in non-small cell lung cancer cells. Proc Natl Acad Sci, USA. 110(42):16868-73
Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ (2012) ROCK1 and ROCK2 are required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion. Cancer Res. 72(20):5338-47
Kim TY, Vigil D, Der CJ, Juliano RL (2009) Role of DLC-1, a Tumor Suppressor Protein with RhoGAP activity, in Regulation of the Cytoskeleton and Cell Motility. Cancer Metastasis Reviews28(1-2):77-83.
Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, and Bang YJ. (2008) Transcriptional Induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. Exp Mol Med 40 (6):639-46.
Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL (2008) Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration. J Biol Chem 283(47): 32762-70.
SchrampM, Ying O, Kim TY, Martin GS. (2008) ERK5 Promotes Src-induced Podosome Formation by limiting Rho activation. J Cell Biol. 181(7):1195-210.
Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. (2008) DLC-1 Suppresses Non-Small Cell Lung Cancer Growth and Invasion by RhoGAP-Dependent and Independent Mechanisms. Mol Carcinog. 47(5):326-37.
Jung Y, Park J, Kim TY, Park JH, Jong HS, Im SA, Robertson KD, Bang YJ, Kim TY. (2007). Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy. J Mol Med. 85(10):1137-48.
Kim TY, Lee JW, Kim HP, Jong HS, Kim TY, and Bang YJ. (2007) DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun. 355(1):72-7.
Lee KW, Kim JH, Park JH, Kim HP, Song SH, Kim SG, Kim TY, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2006). Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells. Anticancer Res. 26(5A):3429-38.
Lee SY, Kim TY, Lee MS, Kim YB, Chung E, Kim S, Lee JW. (2006). Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. Exp Cell Res. 312(16):2983-99.
Juliano RL, Dixit VR, Kang H, Kim TY, Miyamoto Y, Xu D. (2005). Epigenetic manipulation of gene expression: a toolkit for cell biologists. J. Cell Biol. 169(6):847-57
Kim JH, Lee KW, Jung Y, Kim TY, Ham HS, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2005). Cytotoxic effects of pemetrexed in gastric cancer cells. Cancer Sci. 96(6):365-71.
Kim HP, Kim TY, Lee MS, Jong HS, Kim TY, Lee JW, Bang YJ. (2005). TGF-1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27Kip1 CDK inhibitor in hepatoma cells replated on fibronectin. Biochim Biophys Acta (BBA)-Mol Cell Res. 1743(1-2):151-61.
Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ. (2005). Cyclooxygenase-2 Inhibits Novel Ginseng Metabolite-Mediated Apoptosis. Cancer Res. 65(5):1952-60.
Kim TY, Jong HS, Jung Y, Kim TY, Kang GH, Bang YJ. (2004). DNA hypermethylation in gastric cancer. Aliment Pharmacol Ther., 20 (Suppl 1):131-42.
Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK., Lee JS, Kim NK, Kim TY., Bang Y.J. (2004). Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation. Clin Cancer Res., 10(15):5271-81.
Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK, Bang YJ. (2004). AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene, 23(42):7095-103.
Park J, Song SH, Kim TY, Choi MC, Jong HS, Kim TY, Lee JW, Kim NK, Kim WH, Bang YJ. (2004), Aberrant methylation of integrin beta 4 gene in human gastric cancer cells. Oncogene, 23(19):3474-80.
Kim TY, Lee HS, Hwang KS, Lee, M, Kim JW, Bang YJ, and Kang GH. (2004). Methylation of Runx3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest. , 84(4):479-84.
Kim TY, Jong HS, Song SH, Dimtchev A, Jeong SJ, Lee JW, Kim TY, Kim NK, Jung, M, and Bang Y.J. (2003). Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells Oncogene, 22(25), 3943-3951.
Park JH, Kim TY, Jong HS, Kim TY, Chun YS, Park JW, Lee CT, Jung HC, Kim NK, and Bang YJ. (2003). Gastric Epithelial Reactive Oxygen Species Prevent Normoxic Degradation of Hypoxia-Inducible factor-1 alpha in Gastric Cancer Cells. Clin. Cancer Res., 9(1), 433-440.