Jiwoon Lim
Telephone: +82-10-9187-6930 |
Research Interest
Astrocyte’s role in synapse, memory, and disease
Education
Sep. 2020-present
Mar. 2013-Feb. 2019 | Integrated Course at Institute of Basic Science Principal investigator: Dr. C. Justin Lee
Bachelor of Science and Arts at Korea University First major: Life Sciences Second major: Psychology |
Research Experience
Feb. 2019 - Aug. 2019
Sep. 2017 - Sep. 2019
Dec. 2014 - June 2015 | Research Assistant at Institute of Basic Science Dr. C. Justin Lee’s laboratory Studying on reactive astrocyte, Alzheimer’s disease & storage operated calcium entry system
Internship at Korea Institute of Science and Technology Dr. C. Justin Lee’s laboratory Studying on reactive astrocyte & Alzheimer’s disease
Internship program of Korea University Prof. Bongjune Yoon’s laboratory Setting of CrisprCas9 system & learning mouse surgery and molecular work |
Publication
Chun, H., Kim, Y., Kang, Y., Im, H., Shin, J., Won, W., Lim, J., Ju, Y., Park, Y., Kim, S., Lee, J., Woo, J., Hwang, Y., Jo, S., Wetzel I., Park, J., Kim, D., Kim, D., Gwag, B., Kim, Y., & Lee, C J. (2020). Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via excessive H2O2-production. Nature Neuroscience
Kim, W., Won, S. Y., & Yoon, B. (2019). CRMP2 mediates GSK3β actions in the striatum on regulating neuronal structure and mania-like behavior. Journal of Affective Disorders, 245, 1079-1088. In acknowledgement
Chun, H., An, H., Lim, J., Woo, J., Lee, J., Ryu, H., & Lee, C. J. (2018). Astrocytic proBDNF and tonic GABA distinguish active versus reactive astrocytes in hippocampus. Experimental Neurobiology, 27(3), 155-170. |
Poster Exhibition
Lim, J.*, Chun, H.*, Won, J., Park, Y. M., & Lee, C. J. (2019). Mao-b inhibition reduces astrogliosis and transforms reactive astrocytes into active astrocytes under pathological conditions. International Brain Research Organization, Daegu, Korea of Republic |
Lim, J.*, Jee, S., Kwon J., Sa M. & Lee, C. J. (2020). Trifluoperazine (TFP) elevates intracellular Ca2+ level and maintains the open state of the store-operated calcium entry (SOCE) in astrocyte. The Korean Society for Brain and Neural Sciences, Seoul, Korea of Republic
Research Techniques
Mouse Surgery | Perfusion, stereotaxic virus injection, IP injection, oral injection, blood prep from heart, primary cell culture |
Behavior Test
| Open field test, passive avoidance test, contextual fear conditioning, radial arm maze, novel place recognition, rotarod test, tactile discrimination test |
Histology | Cryosection, IHC, controlling confocal imaging system and analyzing (Image J & IMARIS) |
Molecular Work | Genotyping, DNA prep, RNA prep, gel electrophoresis, PCR, qRT PCR |
Calcium Imaging | Calcium ion imaging with FURA-2 at astrocyte cell culture |
Electrophysiology | Cell patch and slice patch |
Microdialysis | Extracting CSF from mouse brain and analyzing endogenous molecule |
Awards, Honors, and Scholarships
Outstanding Intern Award Internship program of the University of Science and Technology
| Feb. 2018 |