CENTER for GENOME ENGINEERING

Publication Date 2023-03

Precision mitochondrial DNA editing with high-fidelity DddA-derived base editors

Seonghyun Lee,Hyunji Lee,Ga Young Baek,Jin Soo Kim

Nature Biotechnology, v.41, no.3, pp.378 - 186

Publication Date 2023-03

Limitations of gene editing assessments in human preimplantation embryos

Liang, Dan,Mikhalchenko, Aleksei,Ma, Hong,Marti Gutierrez, Nuria,Chen, Tailai,Lee, Yeonmi,Sang-Wook Park,Tippner-Hedges, Rebecca,Koski, Amy,Darby, Hayley,Li, Ying,Van Dyken, Crystal,Zhao, Han,Wu, Keliang,Zhang, Jingye,Hou, Zhenzhen,So, Seongjun,Han, Jongsuk,Park, Jumi,Kim, Chong-Jai,Zong, Kai,Gong, Jianhui,Yuan, Yilin,Gu, Ying,Shen, Yue,Olson, Susan B.,Yang, Hui,Battaglia, David,O'Leary, Thomas,Krieg, Sacha A.,Lee, David M.,Wu, Diana H.,Duell, P Barton,Kaul, Sanjiv,Jin Soo Kim,Heitner, Stephen B.,Kang, Eunju,Chen, Zi-Jiang,Amato, Paula,Mitalipov, Shoukhrat

Nature Communications, v.14, no.1

Publication Date 2023-03

Prime editing with genuine Cas9 nickases minimizes unwanted indels

Jaesuk Lee,Kayeong Lim,Annie Kim,Young Gun Mok,Eugene Chung,Sung-Ik Cho,Ji Min Lee,Jin Soo Kim

Nature Communications, v.14, no.1

Publication Date 2023-03

Transcriptomes of the tumor-adjacent normal tissues are more informative than tumors in predicting recurrence in colorectal cancer patients

Kim, Jinho,Kim, Hyunjung,Lee, Min-seok,Heetak Lee,Kim, Yeon Jeong,Lee, Woo Yong,Yun, Seong Hyeon,Kim, Hee Cheol,Hong, Hye Kyung,Hannenhalli, Sridhar,Cho, Yong Beom,Park, Donghyun,Choi, Sun Shim

Journal of Translational Medicine, v.21, no.1

Publication Date 2023-01

Extru-seq: a method for predicting genome-wide Cas9 off-target sites with advantages of both cell-based and in vitro approaches

Kwon, J.,Kim, M.,Hwang, W.,Jo, A.,Hwang, G.-H.,Jung, M.,Kim, U.G.,Cui, G.,Kim, H.,Eom, J.-H.,Hur, J.K.,Lee, J.,Kim, Y.,Jin Soo Kim,Bae, S.,Lee, J.K.

Genome Biology, v.24, no.1

Publication Date 2023-01

A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the developing mouse salivary gland

Chatzeli, Lemonia,Bordeu, Ignacio,Han, Seungmin,Bisetto, Sara,Waheed, Zahra,Bonkyoung Koo,Alcolea, Maria P.,Simons, Benjamin D.

DEVELOPMENTAL CELL, v.58, no.2, pp.94 - 109

Publication Date 2022-12

Targeted A-to-G base editing of chloroplast DNA in plants

Young Gun Mok,Sung Hyun Hong,Su Ji Bae,Sung-Ik Cho,Jin Soo Kim

Nature Plants, v.8, no.12, pp.1378 - 1384

Publication Date 2022-12

SCON—a Short Conditional intrON for conditional knockout with one-step zygote injection

Wu, S.-H.S.,Heetak Lee,Szép-Bakonyi, R.,Colozza, G.,Boese, A.,Gert, K.R.,Hallay, N.,Ji Hyun Lee,Kim, J.,Zhu, Y.,Linssen, M.M.,Pilat-Carotta, S.,Hohenstein, P.,Theussl, H.-C.,Pauli, A.,Bonkyoung Koo

Experimental and Molecular Medicine, v.54, no.12, pp.2188 - 2199

Publication Date 2022-11

Early stage ultraviolet irradiation damage to skin collagen can be suppressed by HPA axis control via controlled CYP11B

Lim, Hye-Sun,Lee, Seung Hoon,Hui Yun Seo,Lee, Hwi-Ho,Yoon, Kyeongno,Kim, Yong-ung,Park, Moon-Ki,Chung, Jin Ho,Lee, Yong-Seok,Lee, Dong Hun,Park, Gunhyuk

Biomedicine and Pharmacotherapy, v.155

Publication Date 2022-11

Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis

Sujin Park,Mossmann, Dirk,Chen, Qian,Wang, Xueya,Dazert, Eva,Colombi, Marco,Schmidt, Alexander,Ryback, Brendan,Ng, Charlotte K. Y.,Terracciano, Luigi M.,Heim, Markus H.,Hall, Michael N.

MOLECULAR CELL, v.82, no.22, pp.4246 - 4261