Tai Young Kim
Cholesteol metablisim in glioblastoma, Indentification of interacting proteins using BioID, Drug development against COVID-19 coronavirus (SARS-CoV-2)
EDUCATION
2002 Ph.D.
in Tumor Biology, Seoul National University, College of Medicine, Korea (advisor:
Yung-Jue Bang)
1996 M.S.
in Microbiology, Seoul National University, Korea (advisor: Gajin Jeong)
1993 B.S.
in Microbiology, Hankuk University of Foreign Studies, Korea.
PROFESSIONAL
EXPERIENCES
06/2020 – Current Senior Researcher, Center for Cognitive and Sociality, Institute for Basic Science, Daejeon, Korea
01/2019 –
05/2020 Research Fellow, Cognitive
Glioscience Group, Center for Cognitive and Sociality, Institute for Basic
Science, Daejeon,
Korea
11/2015 – 12/2018 Research Professor, Kyung Hee University
Korean Medicine, Korea.
01/2014 – 10/2015
Principal Research Scientist, Research Institute
of Pharmaceutical Sciences, College of Pharmacy, Seoul National
University,
Korea.
08/2013 – 12/2013
Research Associate Professor, School of
Nano-Bioscience and Chemical Engineering, UNIST, Republic of Korea
01/2009 - 07/2013
Postdoctoral Research Associate, Lineberger
Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC
(Advisor:
Channing J. Der)
01/2004 - 12/2008 Postdoctoral Research Associate, Department of
Pharmacology, University of North Carolina, Chapel Hill, NC
(Advisor: Rudy L.
Juliano)
08/2002 - 12/2003 Postdoctoral Research Associate, Cancer
Research Institute, Seoul National University, Korea (advisor: Yung-Jue Bang)
07/1998 - 03/1999 M.S. Researcher, Cancer Research Institute,
Seoul National University, Korea
AWARDS and FELLOWSHIPS
2016-2019 Research Fellow Grant, Ministry of Education,
Korea of Republic
2013–2016 Research
Fellow Grant, Ministry of Education, Korea of Republic
2009-2011 Susan
G. Komen Research Grant
2003 Young
Researcher Awards in Seoul National University Cancer Research Institute
PUBLICATION
Jang MW, Oh D, Yi E, Liu X, Ling J, Kim N, Sharma K, Kim TY, Lee S, Kim AR, Kim MY, Kim MA, Lee M, Han JH, Han JJ, Park HR, Kim BJ, Lee SY, Woo DH, Oh J, Oh SJ, Du T, Koo JW, Oh SH, Shin HW, Seong MW, Lee KY, Kim UK, Shin JB, Sang S, Cai X, Mei L, He C, Blanton SH, Chen ZY, Chen H, Liu X, Nourbakhsh A, Huang Z, Kang KW, Park WY, Feng Y, Lee CJ, Choi BY (2021) A nonsense TMEM43 variant leads to disruption of connexin-linked function and autosomal dominant auditory neuropathy spectrum disorder. Proc Natl Acad Sci, USA. Jun 1;118(22)
Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim ST, Lee CJ (2021) Platycodin D, a natural product from Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med, May;53(5):956-972
Lee SJ, Choi YJ, Kim HI, Moon HE, Baek SH, Kim TY, Ko SG (2021) LDLR facilitates platycodin D-induced autophagy inhibition.and cell death in glioblastoma cells. Mol Oncol. May 1 *Co-corresponding Author.
Kim HI, Lee SJ, Choi YJ, Kim MJ, Kim TY, Ko SG (2021) Quercetin induces apoptosis in glioblastoma cell lines U87MG and U373MG by suppressing Axl/IL-6/STAT3 signaling pathway. Am J Chin Med, Mar 3;1-18. *Co-corresponding Author
Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG. (2020) Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells. Sci Rep, Nov 16;10(1):1983. *Co-corresponding Author
Won J, Lee S, Park M, Kim TY, Park MG, Choi BY, Kim D, Chang H, Kim VN, Lee CJ (2020) Development of a Laboratory-safe and Low-cost Detection Protocol for SARS-CoV-2 of the Coronavirus Disease 2019 (COVID-19). Exp Neurobiol, Apr 30; 29(2):107-119.
Hong SH, Ku JM, Kim HI, Kim TY, Seo HS, Shin YC, Ko SG (2019) Topical Application of KAJD Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis Symptoms Through Regulation of IgE and MAPK Pathways in BALB/C Mice and Several Immune Cell Types. Front Pharmacol. Sep 19; 10:1097.
Kim HI, Hong SH, Ku JM, Lim YS, Lee SJ, Song J, Kim TY, Cheon C, Ko SG. (2019) Scutellaria Radix Promotes Apoptosis in Non-Small Cell Lung Cancer Cells via Induction of AMPK-Dependent Autophagy. Am J Chin Med. 47(3):691-705
Ku JM, Hong SH, Kim SR, Choi HS, Kim HI, Kim DU, Oh SM, Seo HS, Kim TY, c, Cheon C, Ko SG. (2018) Novel mechanism The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo. BMC Complement Altern Med. Jul 13;18(1):215
Kim HI, Hong SH, Ku JM, Kang S, Kim TY, Shin YC, Ko SG. (2017) Tonggyu-tang, a traditional Korean medicine, suppresses pro-inflammatory cytokine production through inhibition of MAPK and NF-κB activation in human mast cells and keratinocytes. BMC Complement Altern Med. Mar 31;17(1):186
Kim HJ, Kwon S, Nam SH, Jung JW, Kang M, Ryu J, Kim JE, Cheong JG, Cho CY, Kim S, Song DG, Kim YN, Kim TY, Jung MK, Lee KM, Pack CG, Lee JW. (2017) Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments.FASEB J. 2017, 31(4):1461-1481.
Choi J, Kang M, Nam SH, Lee GH, Kim HJ, Ryu J, Cheong JG, Jung JW, Kim TY, Lee HY, Lee JW (2015) Bidirectional signaling between TM4SF5 and IGF1R promotes resistance to EGFR kinase inhibitors. Lung Cancer, 90(1):22-31
Nam SH, Kim D, Lee MS, Lee D, Kwak TK, Kang MK, Ryu J, Kim HJ, Song HE, Choi J, Lee GH, Kim SY, Park SH, Kim DG, Kwon NH, Kim TY, Thiery JP, Kim S, and Lee JW (2015) Noncanonical roles of membranous lysyl-tRNA synthetase in transducing cell-substrate signaling for invasive dissemination of colon cancer spheroids in 3D collagen I gels. Oncotarget, 6(25): 21655-74
Lee D, Na J, Ryu J, Kim HJ, Nam SH, Kang M, Jung JW, Lee MS, Song HE, Choi J, Lee GH, Kim TY, Chung JK, Park KH, Kim SH, Kim H, Seo H, Kim P, Youn H, Lee JW (2015) Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells. Hepatology, 61(6):1978-97
Kim TY, Seisser PM, Rossman KL, Goldfarb D, Mackinnon K, Yan F, Yi X, MacCoss, M, Moon RT, Der CJ, Major MB (2015) Substrate Trapping Proteomics Reveals Targets of the βTrCP2/FBXW11 Ubiquitin Ligase. Mol Cell Biol, 35(1):167-81
Kang M, Ryu J, Lee D, Lee MS, Kim HJ, Nam SH, Song HE, Choi J, Lee GH, Kim TY, Lee H, Kim SJ, Ye SK, Kim S, Lee JW (2014) Correlations between Transmembrane 4 L6 Family Member 5 (TM4SF5), CD151, and CD63 in Liver Fibrotic Phenotypes and Hepatic Migration and Invasive Capacities. PLoS One. 9(7):e102817
Lee MS, Kim S, Kim BG, Won C, Nam SH, Kang S, Kim HJ, Kang M, Ryu J, Song HE, Lee D, Ye SK, Jeon NL, Kim TY, Cho NH, Lee JW (2014) Snail1 induced in breast cancer cells in 3D collagen I gel environment suppresses cortactin and impairs effective invadopodia formation. Biochim Biophys Acta. 1843(9):2037-54
Kim TY, Jackson S, Xiong Y, Whitsett TG, Lobello JR, Tran NL, Malek NP, Bang YJ, Der CJ (2013) Loss of DLC1 RhoGAP tumor suppressor expression and function by CUL4A-DDB1-FBXW5-dependent ubiquitination and degradation in non-small cell lung cancer cells. Proc Natl Acad Sci, USA. 110(42):16868-73
Vigil D, Kim TY, Plachco A, Garton AJ, Castaldo L, Pachter JA, Dong H, Chen X, Tokar B, Campbell SL, Der CJ (2012) ROCK1 and ROCK2 are required for Non-Small Cell Lung Cancer Anchorage-Independent Growth and Invasion. Cancer Res. 72(20):5338-47
Kim TY, Vigil D, Der CJ, Juliano RL (2009) Role of DLC-1, a Tumor Suppressor Protein with RhoGAP activity, in Regulation of the Cytoskeleton and Cell Motility. Cancer Metastasis Reviews28(1-2):77-83.
Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M, and Bang YJ. (2008) Transcriptional Induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. Exp Mol Med 40 (6):639-46.
Kim TY, Healy KD, Der CJ, Sciaky N, Bang YJ, Juliano RL (2008) Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration. J Biol Chem 283(47): 32762-70.
SchrampM, Ying O, Kim TY, Martin GS. (2008) ERK5 Promotes Src-induced Podosome Formation by limiting Rho activation. J Cell Biol. 181(7):1195-210.
Healy KD, Hodgson L, Kim TY, Shutes A, Maddileti S, Juliano RL, Hahn KM, Harden TK, Bang YJ, Der CJ. (2008) DLC-1 Suppresses Non-Small Cell Lung Cancer Growth and Invasion by RhoGAP-Dependent and Independent Mechanisms. Mol Carcinog. 47(5):326-37.
Jung Y, Park J, Kim TY, Park JH, Jong HS, Im SA, Robertson KD, Bang YJ, Kim TY. (2007). Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy. J Mol Med. 85(10):1137-48.
Kim TY, Lee JW, Kim HP, Jong HS, Kim TY, and Bang YJ. (2007) DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun. 355(1):72-7.
Lee KW, Kim JH, Park JH, Kim HP, Song SH, Kim SG, Kim TY, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2006). Antitumor Activity of SK-7041, a Novel Histone Deacetylase Inhibitor, in Human Lung and Breast Cancer Cells. Anticancer Res. 26(5A):3429-38.
Lee SY, Kim TY, Lee MS, Kim YB, Chung E, Kim S, Lee JW. (2006). Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. Exp Cell Res. 312(16):2983-99.
Juliano RL, Dixit VR, Kang H, Kim TY, Miyamoto Y, Xu D. (2005). Epigenetic manipulation of gene expression: a toolkit for cell biologists. J. Cell Biol. 169(6):847-57
Kim JH, Lee KW, Jung Y, Kim TY, Ham HS, Jong HS, Jung KH, Im SA, Kim TY, Kim NK, Bang YJ. (2005). Cytotoxic effects of pemetrexed in gastric cancer cells. Cancer Sci. 96(6):365-71.
Kim HP, Kim TY, Lee MS, Jong HS, Kim TY, Lee JW, Bang YJ. (2005). TGF-1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27Kip1 CDK inhibitor in hepatoma cells replated on fibronectin. Biochim Biophys Acta (BBA)-Mol Cell Res. 1743(1-2):151-61.
Yim HW, Jong HS, Kim TY, Choi HH, Kim SG, Song SH, Kim J, Ko SG, Lee JW, Kim TY, Bang YJ. (2005). Cyclooxygenase-2 Inhibits Novel Ginseng Metabolite-Mediated Apoptosis. Cancer Res. 65(5):1952-60.
Kim TY, Jong HS, Jung Y, Kim TY, Kang GH, Bang YJ. (2004). DNA hypermethylation in gastric cancer. Aliment Pharmacol Ther., 20 (Suppl 1):131-42.
Park JH, Jung Y, Kim TY, Kim SG, Jong HS, Lee JW, Kim DK., Lee JS, Kim NK, Kim TY., Bang Y.J. (2004). Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation. Clin Cancer Res., 10(15):5271-81.
Choi MC, Jong HS, Kim TY, Song SH, Lee DS, Lee JW, Kim TY, Kim NK, Bang YJ. (2004). AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene, 23(42):7095-103.
Park J, Song SH, Kim TY, Choi MC, Jong HS, Kim TY, Lee JW, Kim NK, Kim WH, Bang YJ. (2004), Aberrant methylation of integrin beta 4 gene in human gastric cancer cells. Oncogene, 23(19):3474-80.
Kim TY, Lee HS, Hwang KS, Lee, M, Kim JW, Bang YJ, and Kang GH. (2004). Methylation of Runx3 in various types of human cancers and premalignant stages of gastric carcinoma. Lab Invest. , 84(4):479-84.
Kim TY, Jong HS, Song SH, Dimtchev A, Jeong SJ, Lee JW, Kim TY, Kim NK, Jung, M, and Bang Y.J. (2003). Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells Oncogene, 22(25), 3943-3951.
Park JH, Kim TY, Jong HS, Kim TY, Chun YS, Park JW, Lee CT, Jung HC, Kim NK, and Bang YJ. (2003). Gastric Epithelial Reactive Oxygen Species Prevent Normoxic Degradation of Hypoxia-Inducible factor-1 alpha in Gastric Cancer Cells. Clin. Cancer Res., 9(1), 433-440.
Curriculum Vitae (last updated: 02-25-2022)
PERSONAL AND PROFESSIONAL INFORMATION
Name: Ki Jung Kim, Ph.D.
Institute for Basic Science: Senior Researcher
Professional Address: Center for Cognition and Sociality
Institute for Basic Science
55, Expo-ro, Yuseong-gu, Daejeon, 34126
Republic of Korea
Telephone: +82-10-8371-5855, Fax: +82-42-878-9151
E-mail: kjkim@ibs.re.kr
Google Scholar: Ki Jung Kim
EDUCATION
Kyung Hee University, Yongin-si, Kyeongggi-do, South Korea
Bachelor of Science in Genetic Engineering (1996-2000)
Catholic University of Korea, College of Medicine, Seoul, South Korea
Master of Science in Neuropharmacology (2002-2004)
Advisor: Prof. Ki-Wug Sung (MD., Ph.D.)
Catholic University of Korea, College of Medicine, Seoul, South Korea
Ph.D in Neurobiology (2004-2009)
Advisor: Prof. Ki-Wug Sung (MD., Ph.D.)
RESEARCH AND PROFESSIONAL EXPERIENCE
Research Assistance (Sep. 2002-Apr. 2009)
Department of Pharmacology
Catholic University of Korea, College of Medicine
Seoul, South Korea
Postdoctoral Associate (Jun. 2009-Aug. 2019)
Department of Physiology
Medical College of Georgia
Augusta University, GA, USA
Supervisor: Dr. Jessica A. Filosa
Senior Research Associate (Sep. 2019- Jun. 2021)
Department of Physiology
Medical College of Georgia
Augusta University, GA, USA
Principal Investigator: Dr. Jessica A. Filosa
Senior Researcher (Jul. 2021 - Present)
Center for Cognition and Sociality
Institute for Basic Science
55, Expo-ro, Yuseong-gu, Daejeon, 34126
Republic of Korea
SCIENTIFIC PUBLICATIONS
PEER REVIEW ARTICLES
PUBLISHED
Ki Jung Kim, Juan Ramiro Diaz, Jessica L. Presa, Robinson Muller, Michael W. Brands, Mohammad B. Khan, David C. Hess, and Jessica A. Filosa. (2021) Decreased parenchymal arteriole tone in a mouse model of vascular cognitive impairment uncouples vessel-to-neuronal communication. GeroScience. 2021 Jan 7. (https://doi.org/10.1007/s11357-020-00305-x)
*Ramiro-Diaz, JM., *Kim, KJ., Brands, M and Filosa, JA. (2019) Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice. Glia. 2018 Dec 2. PMID: 30506941. (*Co-First Author).
This article was recommended in F1000 Prime.
Ki Jung Kim, Seung Hyun Jeun and Ki-Wug Sung (2017) Lamotrigine, an antiepileptic drug, inhibits 5-HT3 receptor currents in NCB-20 neuroblastoma cells. Korean J Physiol Pharmacol. Mar;21(2):169-177. PMID: 28280410.
Kim, KJ., Ramiro-Diaz JM., Iddings, JA., Filosa, JA. (2016) Vasculo-Neuronal Coupling: Retrograde Vascular Communication to Brain Neurons. J Neurosci. 36(50):12624-12639. PMID: 27821575.
This article was recommended in Faculty1000.
Kim, KJ., Iddings, JA., Stern, JE., Blanco, V.M., Kirov, SA., Croom, D., Filosa, JA. (2015) Astrocyte contribution to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci. 27;35(21):8245-57. PMID:26019339.
Iddings, J.A., Kim, KJ., Zhou, Y., Higashimori, H., Filosa, J.A. (2015) Enhanced parenchymal arteriole tone and astrocyte signaling protect neurovascular coupling mediated parenchymal arteriole vasodilation in the spontaneously hypertensive rat. Journal of Cerebral Blood Flow and Metabolism. 35 (7), 1127-1136. PMID:25757753.
Ki Jung Kim, and Jessica A. Filosa. (2012) Advanced in vitro approach to study neurovascular coupling mechanisms in the brain microcirculation. Journal of Physiology Apr 1;590(Pt 7):1757-70. PMID 22310311.
A perspective article was writing on this paper by Robert Bryan Jr. JPHYSIOL/2012/233718 "No matter - It matters how you slice it".
HyeongSeok Cho, Seung Hyun Jeun, QuingZhong Li, Ki Jung Kim and Ki-Wug Sung. (2012) Involvement of the endocannabinoid system in ethanol-induced corticostriatal synaptic depression. J Pharmacol Sci. 120, 45-49. PMID: 22971846.
QuingZhong Li, HyeongSeok Cho, Seung Hyun Jeun, Ki Jung Kim and Ki-Wug Sung. (2011) Effects of Grape Seed Proanthocyanidin on 5-Hydroxytryptamine3 Receptors in NCB-20 Neuroblastoma Cells. Biol Pharm Bull. 34(7), 1109-1115. PMID: 21720021.
Jeun, SH., Cho, HS., Kim, KJ., Li, QZ., Sung, K-W. (2009) Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum.Korean J Physiol Pharmacol. Jun;13(3):209-14. PMID: 19885039.
Education
March
2002 - August 2010 B.A. Korea University
ü Major:
Business & Administration
ü Minor:
Law
September 2013 - present Ph.D. course, KU-KIST Graduate School of Converging
Science and Technology
ü Major: NBIT (Advanced
educated in Neuroscience)
Researcher,
Center for Cognition and Sociality, Institute for Basic Science (IBS)
Research
Experiments
October
2012 - August 2013 Internship at KIST
ü Center
for Functional Connectomics
Experiment
Techniques
Slice
patch-clamp recording (Neuron, Astrocyte), Cell patch (Astrocyte, HEK293T),
Sniffer patch, Ca2+ imaging, Primary astrocyte culture, Primary
neuron culture, Immunohistochemistry, Immunocytochemistry, Confocal microscope
imaging, SIM imaging, Imaris 3D rendering, PCR, RT-PCR, DNA/RNA prep, Cloning, Sub-cloning,
Stereotaxic surgery (Mouse, Monkey)
Research Interests
ü
Transdiffernentiation,
Treating Spinal Cord Injury (SCI) and neurodegenerative diseases with direct
reprogramming of reactive astrocyte into neuron
ü
Bestrophin1
channel expression related synaptic property
Publications
1.
Tweety-homolog (Ttyh)
Family Encodes the Pore-forming Subunits of the Swelling-dependent
Volume-regulated Anion Channel (VRACswell) in the Brain, Han YE, Kwon J, Won J,
An H, Jang MW, Woo J, Lee JS, Park MG, Yoon BE, Lee SE, Hwang EM, Jung
JY, Park H, Oh SJ, Lee CJ, Exp Neurobiol. 2019 Apr;28(2):183-215
2.
Pharmacological
Dissection of Intrinsic Optical Signal Reveals a Functional Coupling between
Synaptic Activity and Astrocytic Volume Transient, Junsung Woo, Young-Eun Han,
Wuhyun Koh, Joungha Won, Min Gu Park, Heeyoung
An, C. Justin Lee, Exp Neurobiol. 2019 Feb;28(1):30-42
3.
Expression of
µ-Opioid Receptor in CA1 Hippocampal Astrocytes, Min-Ho Nam, Kyung-Seok Han,
Jaekwang Lee, Jin Young Bae, Heeyoung An,
Seahyung Park, Soo-Jin Oh, Eunju Kim, Eunmi Hwang, Yong Chul Bae, C. Justin
Lee, Exp Neurobiol. 2018 Apr; 27(2): 120–128.
4.
Control of motor
coordination by astrocytic tonic GABA release through modulation of
excitation/inhibition balance in cerebellum, Woo J, Min JO, Kang DS, Kim YS,
Jung GH, Park HJ, Kim S, An H, Known
J, Kim J, Shim I, Kim HG, Lee CJ, Yoon BE, Proc Natl Acad Sci U S A. 2018 Apr
24. pii: 1721187115. do (2018)
5.
Cografting
astrocytes improves cell therapeutic outcomes in a Parkinson`s disease model,
Song JJ, Oh SM, Kwon OC, Wulansari N, Lee HS, Chang MY, Lee E, Sun W, Lee SE,
Chang S, An H, Lee CJ, Lee SH, J
Clin Invest 2018 Jan 2;128(1):463-482. (2018)
6.
Astrocytic water
channel aquaporin-4 modulates brain plasticity in both mice and humans: a
potential gliogenetic mechanism underly, J Woo, JE Kim, JJ Im, J Lee, HS Jeong,
S Park, S-Y Jung, H An, S Yoon, SM
Lim, S Lee, J Ma, EY Shin, Y-E Han, B Kim, EH Lee, L Feng, H Chun, B-E Yoon, I
Kang, SR Dager, IK Lyoo and CJ Lee, Molecular Psychiatry advance online
publication 27 June 2017; doi:10.1038/mp.2017.113 (2017)
7.
Orai1 and Orai3
in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry
in Astrocytes, Jea Kwon, Heeyoung An,
Moonsun Sa, Joungha Won,Jeong Im Shin and C. Justin Lee, Exp Neurobiol 2017
Feb;26(1):42-54. (2017)
8.
Differential Cellular
Tropism of Lentivirus and Adeno-Associated Virus in the Brain of Cynomolgus
Monkey, An H, Cho DW, Lee SE, Yang
YS, Han SC, Lee CJ, Exp Neurobiol 2016 Feb;25(1):48-54. doi:
10.5607/en.2016.25.1.48. (2016)
9.
Networked neural
spheroid by neuro-bundle mimicking nervous system created by topology effect,
Jeong GS, Chang JY, Park JS, Lee SA, Park D, Woo J, An H, Lee CJ, Lee SH, Mol Brain 2015 Mar 22;8(1):17. doi:
10.1186/s13041-015-0109-y. (2015)
10. Channel-mediated
astrocytic glutamate modulates hippocampal synaptic plasticity by activating
postsynaptic NMDA receptors, Park H, Han KS, Seo J, Lee J, Dravid SM, Woo J,
Chun H, Cho S, Bae J, An H, Koh W,
Yoon BE, Berlinguer-Palmini R, Mannaioni G, Traynelis SF, Bae Y, Choi SY, Lee
CJ, Mol Brain 2015 Feb 3;8(1):7. (2015)
11. Glial
GABA, synthesized by monoamine oxidase B, mediates tonic inhibition. Bo-Eun
Yoon, JunsungWoo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, JooOkMin, Soo-Jin Oh,
Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Yong Chul Bae and C.
Justin Lee, J Physiol. 2014 Sep 19. DOI: 10.1113 (2014)
Awards
1.
Oral
presentation:
i.
Direct cell
reprogramming of reactive astrocytes into neurons in non-human primate, 2014
KU-KIST symposium
2.
Poster
Presentations:
i.
Transdifferentiation
of scar-forming reactive astrocytes into functional neurons causes motor
recovery after spinal cord injury, 2019 Korea Society for Gene and Cell Therapy
ii.
Cell direct
reprogramming of reactive astrocytes into neurons in non-human primates. 2015
Glia Meeting of the Korean Society for Glia Research
Research interest
Neurodegenerative brain disease and scar forming astrocyte
Education
2004-2011 B.A. in Speech Language Pathology, Korean Nazarene University, Republic of Korea
2012-2015 M.S. in Audiology, Catholic University of Daegu, Republic of Korea (advisor: Chul-Hee Choi)
2016-2019 Ph.D. in Medicine (Otology), Dankook University, Republic of Korea (advisor: Jae Yun Jung)
Research Experiences 2022.01 – Present Postdoc, Center for Cognition and Sociality, Institute for Basic Science (ibs), Republic of Korea 2020.08 - 2022.01 Research Professor, Medical Laser Research Center, Dankook University, Republic of Korea 2015.03 - 2020.08 Research Scientist, Beckman Laser Institute Korea (BLIK), Dankook University, Republic of Korea 2012.08 - 2015.02 Research/Teaching Assistant, Department of Audiology and Speech Language Pathology, Catholic University of Daegu, Republic of Korea 2010.01- 2010.12 International Intern, Communication Disorder Center (CDC), Crotched Mountain Rehabilitation Center (CMRC), United States
|
Awards and Honors
2020 Best poster presentation, the 94th annual congress of Korean Society of Otorhinolaryngology-Head and Neck Surgery, Republic of Korea
2019 Travel Award, the 42th Annual Midwinter Research Meeting of the Association for Research in Otolaryngology (ARO), United States
2018 Best presentation award, 38th Aju otology symposium, Republic of Korea
2017 Best presentation awards, 1st Otology basic research seminar, Korean Otological Society, Republic of Korea
2018 Best presentation award, Korean Society for Laser Medicine and Surgery, Republic of Korea
Grants
2020.09 – 2023.05
Title: Investigation on the role of Ca buffer protein in noise-induced cochlear synaptopathy, National Research Foundation of Korea (NRF), 180,000k KRW
2019.09 – 2020.08
Title: Neuroprotective effect of photobiomodulation mechanism study in secondary ganglion neuron degeneration model, National Research Foundation of Korea (NRF), 45,000k KRW
Publications
1. Lee JH, Carpena NT, Kim s, Lee MY, Jung JY, Choi JE. Photobiomodulation at a wavelength of 633 nm leads to faster functional recovery than 804 nm after facial nerve injury. Journal of Biophotonics. 2021 Jul 12:e202100159. (Front cover image)
2. Kim JH, Jeon S, Choi HD, Lee JH, Bae JS, Kim N, Kim HG, Kim KB, Kim HR. Exposure to long-term evolution radiofrequency electromagnetic fields decreases neuroblastoma cell proliferation via Akt/mTOR-mediated cellular senescence. Journal of Toxicology and Environmental Health, Part A. 2021 Jul 3:1-2.
3. Kim MT, Lee JH, Carpena NT, Lee MY, Chung PS, Jung JY. Estrogen replacement reduces hearing threshold shifts and cochlear hair cell loss after acoustic overexposure in ovariectomized rats. Clinical and Experimental Otorhinolaryngology. 2021 Feb;14(1):61. (co-first author)
4. Lee JH, Lee MY, Choi JE, Jung JY. Auditory Brainstem Response to Paired Click Stimulation as an Indicator of Peripheral Synaptic Health in Noise-Induced Cochlear Synaptopathy. Frontiers in Neuroscience. 2021;14: 596670.
5. Lee JH, Jung JY, Park I. A Gap Prepulse with a Principal Stimulus Yields a Combined Auditory Late Response. Journal of Audiology & Otology. 2020 Jul;24(3):149.
6. Lee JH, Lee MY, Chung PS, Jung JY. Photobiomodulation using low‐level 808 nm diode laser rescues cochlear synaptopathy after acoustic overexposure in rat. Journal of Biophotonics. 2019 Nov;12(11):e201900145.
7. Choi JE, Lee JH, Chang SY, Lee MY, Jung JY. Clinical Implications of Poloxamer 407 as Packing Material in an Animal Model. Audiology and Neurotology. 2019;24(2):100-8.
8, Lee JH, Kim S, Jung JY, Lee MY. Applications of photobiomodulation in hearing research: from bench to clinic. Biomedical Engineering Letters. 2019 Aug;9(3):351-8.
9. Kim JH, Huh YH, Lee JH, Jung JY, Ahn SC, Kim HR. Early exposure to radiofrequency electromagnetic fields at 1850 MHz affects auditory circuits in early postnatal mice. Scientific Reports. 2019 Jan 23;9(1):1-0.
10. Lee JH, Lee MY, Chung PS, Jung JY. Secondary degeneration of auditory neurons after topical aminoglycoside administration in a Gerbil model. Biomed Research International. 2018 Mar 1;2018.
11. Lee MY, Bae SH, Chang SY, Lee JH, Kim SH, Ahn JC, Chung PS, Moy W, Jung JY. Photobiomodulation by laser therapy rescued auditory neuropathy induced by ouabain. Neuroscience Letters. 2016 Oct 28;633:165-73.
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