1. EDUCATION:
- B.S. 2002/2 Biotechnology
Department of Biotechnology, Yonsei University, Seoul, Korea
- M.S. 2004/2 Microbialgenetics
School of Biological Sciences, SeoulNationalUniversity,Seoul,Korea
Dissertation Title: “Genetic Engineering to Improve the Zymomonas mobilis ZM4”
Advisor: Hyen Sam Kang, Ph.D.
- Ph.D. 2014/2 Neuroscience
Department of Craniomaxillofacial Cell and Developmental Biology
School of Dentistry,SeoulNationalUniversity,Seoul,Korea
Dissertation Title: “Expression, Function and Regulation of Bestrophin-1 Channel in Astrocyte”
Advisor: Seungbok Lee, Ph.D. and C. Justin Lee, Ph.D.
2. RESEARCH EXPERIENCE:
Jun. 2000 ~ Feb. 2001 Research assistant in Biochemistry and virus laboratory (Advisor: Baik-Lin Seong, Ph.D. professor in Yonsei University)
Sep. 2002 ~ Jun. 2003 Teaching assistant in School of Biological Sciences, Seoul National University
Jan. 2004 ~ Mar. 2005 Research Scientist in Biomedical Center, KIST (Korea Institute of Science and Technology. Advisor: Yeon Gyu Yu, Ph.D. Principal Research Scientist in KIST)
Apr. 2005 ~ Feb. 2016 Research Scientist in Center for Neuroscience, KIST (Korea Institute of Science and Technology. Advisor: C. Justin Lee, Ph.D. Principal Research Scientist in KIST)
Jun. 2012 ~ Jul. 2012 Visiting researcher in The Marine Biological Laboratory (MBL) in Woods Hole
Mar. 2016 ~ Present Senior Research Scientist in Convergence Research Center for Diagnosis, Treatment and Care System of Dementia and Center for Glia-Neuron interaction, KIST (Korea Institute of Science and Technology)
3. PUBLICATIONS :
1. Jeong-Sun Seo, Hyonyong Chong, Hyun Seok Park, Kyoung-Oh Yoon, Cholhee Jung, Jae Joon Kim, Jin Han Hong, Hyungtae Kim, Jeong-Hyun Kim, Joon-Il Kil, Cheol Ju Park, Hyun-Myung Oh, Jung-Soon Lee, Su-Jung Jin, Hye-Won Um, Hee-Jong Lee, Soo-JinOh, Jae Young Kim, Hyung Lyun Kang, Se Yong Lee, Kye Joon Lee and Hyen Sam Kang. “The genome sequence of the ethanologenic bacterium Zymomonas mobilis ZM4” Nature Biotechnology (2004) 23: 63-68
2. Soo-JinOh, JungHwanPark,SungyuHan,JaeKyunLee,EunJooRohandCJustinLee.“DevelopmentofselectiveblockersforCa2+-activatedCl-channelusingXenopus laevis oocytes with an improved drug screening strategy” Molecular Brain (2008) 1: 14-24 [first author]
3. Yun-Kyoung Kim, Soo-JinOh, Bong-Suk Jin, ChanhooPark,HyesungJeon,DooWanBoo,andYeonGyuYu.“Acell-basedmethodtomonitortheinteractionbetweenhepatitisBviruscapsidandsurfaceproteins”Bulletin of the Korean Chemical Society (2009) 30: 577-581
4. Mihye Lee, Sang Kyoo Paik, Min-Jung Lee, Yoon-Jung Kim, Sungdae Kim, Minyeop Nahm, Soo-JinOh, Hyun-Man Kim, Jeongbin Yim, C. Justin Lee, Yong Chul Bae and Seungbok Lee. “Drosophila atlastin regulates the stability of muscle microtubules and is required for synapse development” Developmental Biology (2009) 330: 250-262
5. HyungjuPark*,Soo-JinOh*, Kyung-Seok Han, Dong Ho Woo, HyekyungPark,GuidoMannaioni,StephenF.Traynelis,andC.JustinLee.“Bestrophin-1encodesfortheCa2+-activatedanionchannelinhippocampalastrocytes” The Journal of Neuroscience (2009) 29: 13063-13073 [*co-first authors]
6. Soojung Lee, Bo-Eun Yoon, Ken Berglund, Soo-JinOh, HyungjuPark,Hee-SupShin,GeorgeJ.Augustine,C.JustinLee.“Channel-mediatedtonicGABAreleasefromglia”Science (2010) 330: 790-796
7. Rae Hyung Ryu, Soo-JinOh, Ra Mi Lee, Seong Won Jeong, Lily Yeh Jan, Chi Ho Lee, C. Justin Lee, Sang Min Jeong. “Cloning and heterologous expression of new xANO2 from Xenopus laevis” Biochemical and Biophysical Research Communications (2011) 408: 559-565
8. Ra Mi Lee, Rae Hyung Ryu, Seong Won Jeong, Soo-JinOh, Hue Huang, Jin Soo Han, Chi Ho Lee, C. Justin Lee, Lily Yeh Jan, and Sang Min Jeong. “Isolation and Expression Profile of the Ca2+-ActivatedChlorideChannel-likeMembraneProtein6GeneinXenopus laevis” Laboratory Animal Research (2011) 27: 109-116
9. Dong Ho Woo, Kyung-Seok Han, Jae Wan Shim, Bo-Eun Yoon, Eunju Kim, Jin Young Bae, Soo-JinOh, Eun Mi Hwang, Alan D. Marmorstein, Yong Chul Bae, Jae-Yong Park, and C. Justin Lee. “TREK-1 and Best1 Channels Mediate Fast and Slow Glutamate Release in Astrocytes upon GPCR Activation” Cell (2012) 151(1): 25-40
10. Soo-Jin Oh, Kyung-Seok Han, Hyungju Park, Dong Ho Woo, Hye Yun Kim, Stephen F. Traynelis, and C Justin Lee. “Protease Activated Receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis” Molecular Brain (2012) 5:38 [first author]
11. Soo-JinOh, Seok Jin Hwang, Jonghoon Jung, Kuai Yu, Jeongyeon Kim, Jung Yoon Choi, H.Criss Hartzell, Eun Joo Roh, and C. Justin Lee. “MONNA, a Potent and Selective Blocker for Transmembrane Protein with Unknown Function 16/Anoctamin-1” Molecular Pharmacology (2013) 84:726-735 [first author]
12. Hyungju Park, Kyung-Seok Han, Soo-JinOh, Seonmi Jo, Junsung Woo, Bo-Eun Yoon, and C. Justin Lee. “High glutamate permeability and distal localization of Best1 channel in CA1 hippocampal astrocyte” Molecular Brain (2013) 6:54
13. Seonmi Jo, Oleg Yarishkin, Yu Jin Hwang, Ye Eun Chun, Mijeong Park, Dong Ho Woo, Jin Young Bae, Taekeun Kim, Jaekwang Lee, Heejung Chun, Hyun Jung Park, Da Yong Lee, Jinpyo Hong, Hye Yun Kim, Soo-JinOh, Seung Ju Park, Hyo Lee, Bo-Eun Yoon, YoungSoo Kim, Yong Jeong, Insop Shim, Yong Chul Bae, Jeiwon Cho, Neil W Kowall, Hoon Ryu, Eunmi Hwang, Daesoo Kim and C Justin Lee. “GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease” Nature Medicine (2014) doi:10.1038/nm.3639
14. Seung Eun Lee, Jaekwang Lee, Charles Latchoumane, Boyoung Lee, Soo-JinOh, Zahangir Alam Saud, Cheongdahm Park, Ning Sun, Eunji Cheong, Chien-Chang Chen, Eui-Ju Choi, C. Justin Lee, and Hee-Sup Shin. “Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice” PNAS (2014) 111(32): 11828-11833
15. Bo-Eun Yoon, Junsung Woo, Ye-Eun Chun, Heejung Chun, Seonmi Jo, Jin Young Bae, Heeyoung An, Joo Ok Min, Soo-JinOh, Kyung-Seok Han, Hye Yun Kim, Taekeun Kim, Young Soo Kim, Young Chul Bae, and C. Justin Lee. “Glial GABA, synthesized by monoamine oxidase B, mediates tonic inhibition” The Journal of Physiology (2014) Sep 19
4. PATENTS :
1. Use of anthranillic acid derivatives on calcium activated chloride channel (#10-0892591 02-Apr-2009)
2. Cellular imaging of the interaction between HBV capsid and surface proteins, and its application for screening of inhibitory ag (#10-0949310 17-Mar-2010)
3. Method for screening a glutamate release inhibitor in an astrocyte (#8,871,463 28-Oct-2014, # 10-1418061 3-Jul-2014)
4. Novel compounds as chloride channel blocking agent (#10-1464280 17-Nov-2014)
5. AWARDS and HONORS :
Brain Korea 21 (BK21) Scholarship (2002 - 2003)
KIST우수연구개발팀상 (2011)
Poster award in 2014 BSI symposium in Korea
Poster award in 2016 The Glia Section of the Korea Society of Brain and Neural Science
Travel award in Japan Neuroscience Society 2016
6. POSTER Presentation :
1. The 12th Japan-Korea Joint symposium on Drug Design and Development Jun-2008
Title: Synthesis and biological activities of anthranilic acid derivatives as Ca2+activatedCl-channelblockers
2. International Society for Neurochemistry Aug-2009
Title: Bestrophin-1 Encodes for the Ca2+ActivatedAnionChannelinhippocampalastrocytes
3. Society For Neuroscience Nov-2010
Title: Astrocytic Ca2+-activatedanionchannel,Bestrophin-1,ispermeabletoglutamateandGABA
4. Society For Neuroscience Nov-2013
Title: MONNA, a potent and selective blocker for TMEM16A/Anoctamin-1
5. The Glia Section of the Korea Society of Brain and Neural Science
Title: Ultrasonic brain stimulation modulates neuronal activity via mechano-sensitive TRPA1 channels in astrocytes Jan-2016
postdoctoral fellow | |
KAIST | |
joseonmi@gmail.com |
Intern - Post Bachelor | |
from 2013. 9 to 2014. 8 | |
Currently at KAIST |
Ph.D course | |
Research interest: reactive astrocyte | |
Technique: molecular biology, immunohistochemistry | |
from 2012.4 to 2012.12 | |
gom0303@hanmail.net | |
Currently at KAIST |