Wuhyun Koh
Birth Date : November 12, 1989
Citizenship : Republic of Korea
Tel : +82-10-6361-2748
Email : whvankoh@gmail.com
(general) or whvankoh@ibs.re.kr
(institute)
Current Title : Ph. D. course
EDUCATION
2008.03 ~ 2012.08
B.A. in Korea University, Republic of
Korea
2013.08 ~ 2018.11
Researcher, Center for Functional
Connectomics, Korea Institute of Science and Technology (KIST), Republic of
Korea
2013.08 ~ present
Integrated Ph.D. course, in University of
Science and Technology (UST), Republic of Korea
2018.02 ~ present
Technical Research Personnel (Mandatory
military service in Republic of Korea)
2018.12 ~ present
Researcher, Center for Cognition and
Sociality, Institute for Basic Science (IBS), Republic of Korea
RESEARCH INTERESTS
Astrocyte-Neuron Interaction, Reversal
Learning
PUBLICATIONS
S.-J. Oh, J. Lee, H.-B. Kim, J. Lee, S. Han, J. Bae, G.-S. Hong, W. Koh, J. Kwon, E.-S. Hwang, D.
Woo, I. Youn, I.-J. Cho, Y. Bae, S. Lee, J. Shim, J.-H. Park, J. C. Lee,
Ultrasonic Neuromodulation via Astrocytic TRPA1. Current Biology 29,
3386-797583616 (2019)10.1016/j.cub.2019.08.021).
M.-H. Nam, K.-S. Han, J. Lee, W. Won, W. Koh, J. Bae, J. Woo, J. Kim, E. Kwong, T.-Y. Choi, H.
Chun, S. Lee, S.-B. Kim, K. Park, S.-Y. Choi, Y. Bae, J. C. Lee, Activation of
Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell Reports
28, 1154-116600000 (2019)10.1016/j.celrep.2019.06.071).
J. Woo, Y.-E. Han, W. Koh,
J. Won, M. Park, H. An, J. C. Lee, Pharmacological Dissection of Intrinsic
Optical Signal Reveals a Functional Coupling between Synaptic Activity and
Astrocytic Volume Transient. Experimental Neurobiology 28, 30-42
(2019)10.5607/en.2019.28.1.30).
W. Koh, Y. Park, S. Lee, J. C. Lee, AAV-Mediated Astrocyte-Specific Gene
Expression under Human ALDH1L1 Promoter in Mouse Thalamus. Experimental
Neurobiology 26, 350-361 (2017)10.5607/en.2017.26.6.350).
H. Park, K.-S. Han, J. Seo, J. Lee, S. M. Dravid, J. Woo, H. Chun,
S. Cho, J. Bae, H. An, W. Koh,
B.-E. Yoon, R. Berlinguer-Palmini, G. Mannaioni, S. F. Traynelis, Y. Bae, S.-Y.
Choi, J. C. Lee, Channel-mediated astrocytic glutamate modulates hippocampal
synaptic plasticity by activating postsynaptic NMDA receptors. Molecular Brain
8, 1-16 (2015)10.1186/s13041-015-0097-y).
EXPERIENCES
2009. 06 ~ 2009. 08 48th National
Undergraduate Symposium on Biology (NUSB),
Topic : Mitochondia
2010. 06 ~ 2010. 08 49th National
Undergraduate Symposium on Biology (NUSB),
Topic : Epigenetics
2010. 06 ~ 2011. 03 Undergraduate
Internship Program in Lab of Neuroscience (Dr. Bongjune Yoon), Korea
University, Republic of Korea
2011. 06 SURF (Summer Undergraduate
Research Fellowship) program in Molecular Neuroscience Lab (Dr. JungHoon Kim),
POSTECH, Republic of Korea
2011. 02 ~ 2011. 08 50th National
Undergraduate Symposium on Biology (NUSB) Staff,
Topic : Neuroscience
2012. 06 ~ 2012. 08 51st National
Undergraduate Symposium on Biology (NUSB),
Topic : Bioinformatics
2013. 04 ~ 2013. 08 Undergraduate
Internship Program in Glia-Neuron Interaction Lab
(Dr. C. Justin Lee), KIST, Republic of Korea
AWARDS
1st prize for “Best oral presentation” at the 2018 Brain Science
Institute (BSI) annual meeting held in
Pyeongchang, Republic of Korea
EDUCATION
- 2009.03 ~ 2014.03: B.S. in Korea
University, Seoul, Republic of Korea
- 2015.03 ~ 2022.08: Ph.D course in KU-KIST Graduate School of
Converging Science and Technology, Korea University, Seoul, Republic of Korea
ACADEMIC RESEARCH INTEREST
- Neuroscience (Neuron-glia
interaction)
- Neurodegenerative diseases
- Systemic inflammation
- Reactive oxygen species
(ROS)
-Drug development
- Post-traumatic stress disorder (PTSD)
- Emotions
EXPERIMENTAL TECHNIQUES
- Electrophysiology: Cell patch, Slice
patch
- Imaging: Calcium imaging, Neurotransmitters, sensor probe
- Immunohistochemistry,
Immunocytochemistry
- Molecular biology: Cloning, qRT-PCR, shRNA
- Cellular biology: Transfection,
Microporation
- Astrocyte cell culture
- Behavior test (mouse)
- Stereotaxic surgery (mouse, rat):
virus injection, cannula surgery
- Drug screening
assay (H2O2, MAOB etc.)
- RNA-Sequencing
AWARD and HONORS
■ Oral Presentation award
- 2019 Korean Chemical Society, Division of Medicinal Chemistry; Best Presentation
■ Poster Presentation award
- 2018 Glia Meeting of the Korean Society for Glia Research
- 2019 Cold Spring Harbor Asia (CSHA) meeting, Francis Crick Symposium-Transforming Neurosciences:
Questions & Experiments
- 2021 Korean Society for Brain and Neural Sciences (KSBNS); Best Presentation Award
- 2022 Korean Society for Brain and Neural Sciences (KSBNS); Best Presentation
Award
- 2022 IBS-UNIST Symposium; Best Presentation Award
PATENTS
■ Composition for prevention or treatment of
rheumatoid arthritis (10-2020-0120924)
■ NOVEL AMINOAROMATIC COMPOUNDS OR
PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF
NEURODEGENERATIVE DISEASES COMPRISING THE SAME AS AN ACTIVE INGREDIENT (10-2021-0155076)
■ Prolonging lifespan with long-term administration of novel H2O2 scavenger (10-2022-0092661)
PUBLICATION
1. Won W, Choi HJ, Yoo JY, Kim D, Kim TY, Ju YH, Park KD, Lee H, Jung SY, Lee CJ. inhibiting peripheral and central MAO-B ameliorates both joint inflammation and cognitive impairment in rheumatoid arthritis. Exp Mol Med (in press)
2. An H, Lee H, Yang S, Won W, Lee CJ, Nam MH. Adenovirus-induced Reactive Astrogliosis Exacerbates the Pathology of Parkinson's Disease. Exp Neurobiol. 2021 Jun 30;30(3):222-231. doi: 10.5607/en21013. PMID: 34045369; PMCID: PMC8278136.
3. Kim TY, Jeon S, Jang Y, Gotina L, Won J, Ju YH, Kim S, Jang MW, Won W, Park MG, Pae AN, Han S, Kim ST, Lee CJ. Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion. Exp Mol Med 53, 956–972 (2021).
4. Chun H, Im H, Kang YJ, Kim Y, Shin JH,Won W, Lim J, Ju Y, Park YM, Kim S, Lee SE, Lee J, Woo J, Hwang Y, Cho H, Jo S, Park JH, Kim D, Kim DY, Seo JS, Gwag BJ, Kim YS, Park KD, Kaang BK, Cho H, Ryu H, Lee CJ. Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer's disease via H2O2- production. Nat Neurosci. 2020 Dec;23(12):1555-1566. doi: 10.1038/s41593-020-00735-y. Epub 2020 Nov 16. PMID: 33199896.
5. Nam MH, Cho J, Kwon DH, Park JY, Woo J, Lee JM, Lee S, Ko HY, Won W, Kim RG, Song H, Oh SJ, Choi JW, Park KD, Park EK, Jung H, Kim HS, Lee MC, Yun M, Lee CJ, Kim HI. Excessive Astrocytic GABA Causes Cortical Hypometabolism and Impedes Functional Recovery after Subcortical Stroke.Cell Rep. 2020 Jul 7;32(1):107861. doi: 10.1016/j.celrep.2020.107861. Erratum in: Cell Rep. 2020 Jul 21;32(3):107975. PMID: 32640227.
6. Nam MH*, Won W*, Han KS, Lee CJ. Signaling mechanisms of μ-opioid receptor (MOR) in the hippocampus: disinhibition versus astrocytic glutamate regulation. Cell Mol Life Sci. 2021 Jan;78(2):415-426. doi: 10.1007/s00018-020-03595-8. Epub 2020 Jul 15. PMID: 32671427.
8. Min-Ho Nam, Kyung-Seok Han, Jaekwang Lee, Woojin Won, Wuhyun Koh, Jin Young Bae, Junsung Woo, Jayoung Kim, Elliot Kwong, Tae-Yong Choi, Heejung Chun, Seung Eun Lee, Sang-Bum Kim, Ki Duk Park, Se-Young Choi, Yong Chul Bae, C. Justin Lee. Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference. Cell reports. Volume 28, Issue 5, 30 July 2019, Pages 1154-1166.e5.
- Ph.D course (KU-KIST)
-Glia-neuron interaction, Neurodegeneration and
Neuroinflammation.
-
wwj@ibs.re.kr