Center for
Genomic Integrity

The Orbitrap Fusion Lumos Tribrid Mass Spectrometer is designed to expand performance in advanced proteomics, biopharma and metabolomics applications, including quantitation using isobaric tags, low level PTM analysis, data independent acquisition (DIA), and top down proteomics. The new instrument features enhanced sensitivity resulting in improved analyte detection, characterization and quantitation, enabling scientists to perform more comprehensive sample analyses faster and with better accuracy than ever before. The system is the research-leading high performance mass spectrometer with enhanced sensitivity facilitated by a new High Capacity Transfer Tube, Electrodynamic Ion Funnel, Advanced Quadrupole Technology, Advanced Vacuum Technology, and ETD HD.

• Affinity purification (AP)-MS based DNA integrity regulators interactome profiling
• Post-translational modification (PTM) identification of DNA integrity regulators
• Monitoring protein dynamics at replication fork with SILAC-iPOND analysis
• DNA integrity linked drug target identification
• Differential expressed protein (DEP) profiling