mainmenu
Center for Cognition and SocialityInfrastructure Overview
- Observational Fear
- Rotarod
- 3 chamber
- Rule observance
- Barnes maze
- Ultrasound Vocalization
- Attention behavior
- Sleep analysis
- Field test / object test
- Tube test
- Y maze
The timsTOF fleX is a full-featured, high-speed, high-sensitivity electrospray ionization (ESI) instrument for multi-omics analysis with an integrated marix-assisted laser desorption ionization (MALDI) source for fast MALDI imaging. This instrument is best suited for MALDI imaging of thousands of molecules, such as lipids, peptides, proteins, glycans, and metabolites with higher spatial resolution, improved image acquisition, speed and better molecular specificity. In addition, collisional cross section (CCS) values generated with trapped ion mobility spectrometry (TIMS) device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer enable the detection and separation of isobaric or isomeric ions at low concentration levels that are difficult to separate with other commercially available MALDI imaging instruments.
Massive sequencing tool to describe and analyze genome / transcript information. Seeks for quantified data from DNA, RNA, methylation / epigenetics. Aids research in cancer biology, neuroscience, complex (genomic) disease.
Laboratory animal resource facility Go to site
The animal facility is heavily equipped with various animal behavior test tools, including customized instruments for testing learning & memory, cognition and sociality tasks. Can be used to address instinctive behaviors (fear) to high cognitive functions (empathy). As the core facility for life science research at IBS, the Laboratory Animal Resource Facility(LARF) ensures optimal support for animal experiments with proper care and management of animals. LARF has the capacity to house up to 30,000 mice and 6,000 cages over an area of 4,836m².
The timsTOF fleX is a full-featured, high-speed, high-sensitivity electrospray ionization (ESI) instrument for multi-omics analysis with an integrated marix-assisted laser desorption ionization (MALDI) source for fast MALDI imaging. This instrument is best suited for MALDI imaging of thousands of molecules, such as lipids, peptides, proteins, glycans, and metabolites with higher spatial resolution, improved image acquisition, speed and better molecular specificity. In addition, collisional cross section (CCS) values generated with trapped ion mobility spectrometry (TIMS) device at the front of a quadrupole time-of-flight (QTOF) mass spectrometer enable the detection and separation of isobaric or isomeric ions at low concentration levels that are difficult to separate with other commercially available MALDI imaging instruments.
HPLC is an abbreviation for High Performance Liquid Chromatography. “Chromatography” is a technique for separation, “chromatogram” is the result of chromatography, and “chromatograph” is the instrument used to conduct chromatography. Among the various technologies developed for chromatography, devices dedicated for molecular separation called columns and highperformance pumps for delivering solvent at a stable flow rate are some of the key components of chromatographs. As related technologies became more sophisticated, the system commonly referred to as High Performance Liquid Chromatography, simply became referred to as “LC”. Nowadays, Ultra High Performance Liquid Chromatography (UHPLC), capable of high-speed analysis, has also become more wide-spread.
Q Exactive hybrid quadrupoleOrbitrap mass spectrometer mainly includes an ion source, a stacked-ring ion guide (S-lens), a quadrupole mass filter, a curved linear trap (C-trap), a Higher Energy Collisional Dissociation (HCD) cell, and an Orbitrap mass analyzer. The injection flatapole transmits ions from the source to the quadrupole, which works as ion transmission device with the possibility to filter the transmitted ion according to its mass-to-charge ratios. The ions are transferred into the C-Trap and then injected into the Orbitrap mass analyzer to get mass spectra.
Uses a beam of electrons as a source of illumination, whose wavelength can be up to 100,000 times shorter than that of visible light photons. Has a higher resolving power, about 250 pm resolution and up to about 1,000,000×magnification.
Selected Publications
Nat. Med. 2014 Aug;20(8):886-96, Cell. 2012 Sep 28;151(1):25-40
This system expands access to highperformance imaging and analytics to all levels of microscopy expertise. With ColorSEM Technology, a unique live elemental imaging capability, compositional information is available. Eliminating all the hassle associated with typical EDS implementations, ColorSEM Technology offers unprecedented time to result and ease of use.
- A1R, Nikon
- A1, Nikon
- C2, Nikon
- LSM 700, Zeiss
- LSM 880 Airyscan, Zeiss
- LSM 900, Zeiss
An optical imaging instrument for enhanced optical resolution and contrast by means of using a spatial pinhole to block out-offocus light in image formation. Broadly used to see the detailed structure of objects within specimen.
Enhances the ability to observe complex and dynamic biological processes from deeper within living tissue with minimal invasion and photodamage. This gives a much more effective way for imaging thick specimen.
Structured Illumination Microscopy (SIM) is a super-resolution fluorescence optical microscope imaging technique that increases resolution by patterned light. Stochastic optical reconstruction microscopy (STORM) relies on the sequential activation and time-resolved localization of fluorophores to generate high-resolution images.
Thunder Imagers use an integrative holistic approach to overcome the limitations of camera-based imaging systems. Detects and removes the unwanted signals from out-of-focus regions of the specimen, distinguishes between the out-of-focus and in-focus signals via the difference in size of the features.
Analyze expression of molecules in heterogeneous cell population or particles. Measures physical and chemical characteristics particles using light (laser) and used to determine cell characteristics / function, state of differentiation, and for diagnostic purpose.
A real-time 3D motion reconstruction system to detect whole freely moving behavior in open-field without any marker. The AVATAR system consist of multi-vision hardware and object detection deep learning algorithm that can be used for various mice experiment. This system precisely identifies motion units, a set of body posture/frame, enabling the real-time motion sequencing with sub-millisecond resolution, opening new avenue toward the unsupervised behavioral analysis.
Provide services of viral vector design, cloning, and virus production for gene of interest to the worldwide basic science researchers.
Center for Cognition and Sociality
IBS Center for Cognition and Sociality, Room C211, 55 Expo-ro, Doryong-dong, Yuseong-gu, Daejeon (34126)
Tel Office +82-42-878-8185 LAB +82-42-878-9155
Copyright(c) Center for Cognition and Sociality at IBS. All Rights Reserved.