Center for
Genomic Integrity

Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors

Seula Jeong, Yuheon Chung, Soomin Heo, Kyungjae Myung [NAR Cancer   7, 4(2025) ]

The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models

Soyul Ahn, Seung Eun Baek, Yeuni Yu, Eun Sun Kim, Kyungjae Myung, Yun Hak Kim, Chang-Kyu Oh [European Journal of Medical Research   31, 15(2025) ]

Human coronavirus 3CL protease manipulates host protein STIM1 to facilitate immune evasion

Yoon Young Lee, Ah Reum Lee, Seongkyung Se, Uni Park, Taehun Kim, Sang Kwon Lee, Hyeongsun Jeong, Su Ji Jeong, Yeong Cheon Kweon, Go Eun Park, Min Ji Kim, Byung-Gyu Kim, Taejoon Kwon, Nam-Hyuk Cho, Hyug Moo Kwon, Kyungjae Myung, Sang Min Lee, Chan Young Park [Proceedings of the National Academy of Sciences of the United States of America   122, 48(2025) ]

Proteomic discovery of DEK and NUMA1 as new players in UV-induced DNA damage repair mechanisms

Namwoo Kim, Mihyun Kim, Eunwoo Jeong, Jung-Eun Yeo, Byung-gyu Kim, Kyungjae Myung, Orlando D. Schärer, Kyoo-young Lee [Cell Death Discovery   11, 547(2025) ]

Functional dissection of the conserved C. elegans LEM-3/ANKLE1 nuclease reveals a crucial requirement for the LEM-like and GIY-YIG domains for DNA bridge processing

Junfang Song, Peter Geary, Khadisha Salemova, John Rouse, Ye Hong, Stéphane G M Rolland, Anton Gartner [Nucleic Acids Research   53, 6(2025) ]

When DNA Repair Backfires – Trabectedin Induces DNA Breaks in Active Genes

Vakil Takhaveev, Kook Son, Visesato Mor, Hobin Yu, Emma Dillier, Nicola Zilo, Nikolai J. L. Püllen, Dmitri Ivanov, Helle D. Ulrich, Shana J. Sturia, Orlando D. Schärer [CHIMIA   79. 4; Laureates: Junior Prizes Fall Meeting 2024(2025) ]

TRAP1 functions in the morphogenesis of the embryonic kidney

Ha Eun Kim, Taejoon Kwon, Hyo Jung Sim, Tae Joo Park [Animal Cells and Systems   29, 1(2025) ]

Targeting MMR-deficient colorectal cancer with a potent small molecule UNI110

Enkhzul Amarsanaa, Jung-Min Oh, Seon Young Lee, Saikat Maiti, Sung You Hong, Kyungjae Myung [Animal Cells and Systems   29, 1(2025) ]