Korea VirusResearch Institute

Increased type III interferons and NK cell functions in SARS-CoV-2-infected children

Seong Dong Jeong, Hoyoung Lee, Ju Young Chang, Seong Yong Lee, Ji Eun Choi, Eunmi Yang, Hye Won Jeong, Jae-Phil Choi*, Mi Seon Han*, Eui-Cheol Shin* [Signal Transduction and Targeted Therapy 8:54(2023)]

Adaptive immunity, Innate immunity

Omicron Subvariants, Including BA.4 and BA.5, Substantially Preserve T Cell Epitopes of Ancestral SARS-CoV-2

Kyemyung Park, Seung Jin Choi, Eui-Cheol Shin* [Immune Network 22:4(2022)]

CD4+ T cell, CD8+ T cell, major histocompatibility complex, SARS-CoV-2

CD5 Suppresses IL-15-Induced Proliferation of Human Memory CD8+ T Cells by Inhibiting mTOR Pathways

Young Joon Choi, Hoyoung Lee, Jong Hoon Kim, So-Young Kim, June-Young Koh, Moa Sa, Su-Hyung Park, Eui-Cheol Shin* [Journal of immunology (Baltimore, Md. : 1950) 209:6, 1108-1117(2022)]

IL-15, memory CD8+ T cell, NK cell, CD5, mTOR pathway

Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection

Hye Won Jeong, Se-Mi Kim, Min Kyung Jung, Ji Yun Noh, Ji-Seung Yoo, Eun-Ha Kim, Young-Il Kim, Kwangmin Yu, Seung-Gyu Jang, Juryeon Gil, Mark Anthony Casel, Rollon Rare, Jeong Ho Choi, Hee-Sung Kim, Jun Hyoung Kim, Jihye Um, Chaeyoon Kim, Yeonjae Kim, Bum Sik Chin, Sungmin Jung, Jun Yong Choi, Kyoung-Ho Song, Yong-Dae Kim, Jun-Sun Park, Joon Young Song*, Eui-Cheol Shin*, Young Ki Choi* [Cell Reports Medicine 3:9(2022)]

SARS-CoV-2, recovered patient, variant of concern, Omicron BA.1, Omicron BA.2, mRNA vaccine, T-cell immune response

The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8+ T cell responses

Sungmin Jung, Jae Hyung Jung, Ji Yun Noh, Woo-Joong Kim, Soo-Young Yoon, Jongtak Jung, Eu Suk Kim, Hong Bin Kim, Hee Jin Cheong, Woo Joo Kim, Su-Hyung Park, Kyoung-Ho Song*, Joon Young Song*, Eui-Cheol Shin* [Cell Reports 40:4(2022)]

CD8(+) T cell, COVID-19, CP: Immunology, MHC class I multimer, SARS-CoV-2, memory cell, vaccine

BNT162b2-induced memory T cells respond to the Omicron variant with preserved polyfunctionality

Min Kyung Jung, Seong Dong Jeong, Ji Yun Noh, Dong-Uk Kim, Sungmin Jung, Joon Young Song*, Hye Won Jeong*, Su-Hyung Park*, Eui-Cheol Shin* [NATURE MICROBIOLOGY 7:6, 909-917(2022)]

Viral infection, T cell

Modeling Incorporating the Severity-Reducing Long-term Immunity: Higher Viral Transmission Paradoxically Reduces Severe COVID-19 During Endemic Transition

Hyukpyo Hong, Ji Yun Noh, Hyojung Lee, Sunhwa Choi, Boseung Choi, Jae Kyoung Kim*, Eui-Cheol Shin* [IMMUNE NETWORK 22:3(2022)]

COVID-19, Endemic transition, Immunity, SARS-CoV-2, Severity

Development of Machine Learning Models Predicting Estimated Blood Loss during Liver Transplant Surgery

Sujung Park, Kyemyung Park, Jae Geun Lee, Tae Yang Choi, Sungtaik Heo, Bon-Nyeo Koo*, Dongwoo Chae* [Journal of Personalized Medicine 12, 7-(2022)]

estimated blood loss, liver transplantation, machine learning