Center for
Genomic Integrity

Organ-on-a-Chip Approach for Accelerating Blood-Brain Barrier Nanoshuttle Discovery

Choi Jeong-Won, Kim Kyungha, Mukhambetiyar Karakoz, Lee Na Kyeong, Jonathan Sabaté del Río, Jinmyoung Joo, Park Chun Gwon, Taejoon Kwon, Park Tae-Eun [ACS Nano   18, 22, 14388-14402(2024) ]

SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegans

Odiba Arome Solomon, Ezechukwu Chiemekam Samuel, Liao Guiyan, Hong Ye, Fang Wenxia, Jin Cheng, Anton Gartner, Wang Bin [DNA Repair   137(2024) ]

Mebendazole preferentially inhibits cilia formation and exerts anticancer activity by synergistically augmenting DNA damage

Hong Juyeon, Kwon Keun Yeong, Jang Dong Gil, Taejoon Kwon, Yoon Haejin, Tae Joo Park [Biomedicine & Pharmacotherapy   174(2024) ]

Tardigrades: Trained to be hardy in the face of DNA damage

Stéphane G.M. Rolland, Nadin Memar, Anton Gartner [Current Biology   34, 10, R504-R507(2024) ]

RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

Son Mi Young, Belan Ondrej, Spirek Mario, Cibulka Jakub, Nikulenkov Fedor, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Montagna Cristina, Tae Moon Kim, Krejci Lumir, Hasty Paul [iScience   27, 4(2024) ]

XPA tumor variant leads to defects in NER that sensitize cells to cisplatin

Blee Alexandra M, Gallagher Kaitlyn S, Hyun-Suk Kim, Mihyun Kim, Kharat Suhas S, Troll Christina R, D&apos,Souza Areetha, Jiyoung Park, Neufer P Drew, Orlando D Schärer, Chazin Walter J [NAR Cancer   6, 1(2024) ]

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

Saredi Giulia, Carelli Francesco N., Stephane G. M. Rolland, Furlan Giulia, Piquet Sandra, Appert Alex, Sanchez-Pulido Luis, Price Jonathan L., Alcon Pablo, Lampersberger Lisa, Declais Anne-Cecile, Ramakrishna Navin B., Toth Rachel, Macartney Thomas, Alabert Constance, Ponting Chris P., Polo Sophie E., Miska Eric A., Anton Gartner, Ahringer Julie, Rouse John [Nature Structural & Molecular Biology   31, 3, 523-535(2024) ]

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

Kook Son, Takhaveev Vakil, Visesato Mor, Hobin Yu, Dillier Emma, Zilio Nicola, Püllen Nikolai J. L., Dmitri Ivanov, Ulrich Helle D., Sturla Shana J., Orlando D. Schärer [Nature Communications   15, 1(2024) ]