Korea VirusResearch Institute

Early reduction of regulatory T cells is associated with acute rejection in liver transplantation under tacrolimus-based immunosuppression with basiliximab induction

Ji Won Han, Dong Jin Joo, Jong Hoon Kim, Min-Seok Rha, June Young Koh, Hye Jung Park, Jae Geun Lee, Myoung Soo Kim, Soon Il Kim, Eui-Cheol Shin, Jun Yong Park*, Su-Hyung Park* [American Journal of Transplantation 20:8, 2058-2069(2020)]

immunobiology, immunosuppressant - calcineurin inhibitor (CNI), immunosuppression/immune modulation, liver transplantation/hepatology, lymphocyte biology, rejection, acute, translational research/science

Inducing Transient Mixed Chimerism for Allograft Survival Without Maintenance Immunosuppression With Combined Kidney and Bone Marrow Transplantation: Protocol Optimization

Kyo Won Lee, Jae Berm Park*, Hyojun Park, Yeongbeen Kwon, Ji Soo Lee, Kyeong Sik Kim, Young Jae Chung, Jin Soo Rhu, Sooin Choi, Ghee Young Kwon, Hee Jin Kim, Eun-Suk Kang, Chul Won Jung, Eui-Cheol Shin, Tatsuo Kawai, Sung Joo Kim, Jae-Won Joh [TRANSPLANTATION 104:7, 1472-1482(2020)]

Maintenance Immunosuppression

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Jeong Seok Lee, Seongwan Park, Hye Won Jeong, Jin Young Ahn, Seong Jin Choi, Hoyoung Lee, Baekgyu Choi, Su Kyung Nam, Moa Sa, Ji-Soo Kwon, Su Jin Jeong, Heung Kyu Lee, Sung Ho Park, Su-Hyung Park, Jun Yong Choi*, Sung-Han Kim*, Inkyung Jung*, Eui-Cheol Shin* [SCIENCE IMMUNOLOGY 5:49(2020)]

COVID-19, influenza

IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T cell frequency and increases virus-specific T cell responses

Ji Won Han, Pil Soo Sung, Seon-Hui Hong, Hoyoung Lee, June Young Koh, Hyojin Lee, Scott White, Joel N Maslow, David B Weiner, Su-Hyung Park, Moonsup Jeong, Jeong Heo*, Sang Hoon Ahn*, Eui-Cheol Shin* [JOURNAL OF HEPATOLOGY 73:1, 72-83(2020)]

Chronic hepatitis C, DNA vaccine, IFNL3, Regulatory T cell, T cells

Synovial fluid CD69(+)CD8(+)T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis

Jaehyung Jung, Jung Sun Lee, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Eui-Cheol Shin*, Seokchan Hong* [Synovial fluid CD69(+)CD8(+)T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis 9:6(2020)]

ACPA, CD8+ T cells, citrullination, rheumatoid arthritis, tissue‐resident memory T cells

Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity

Jayoung Ku, Sura Kim, Jaemin Park, Tae-Shin Kim, Raisa Kharbash, Eui-Cheol Shin, Kookheon Char, Yoosik Kim*, Sheng Li* [BIOMACROMOLECULES 21:6, 2440-2454(2020)]

Biopolymers, Genetics, Immunology, Infectious diseases

Functions of human liver CD69(+)CD103(-)CD8(+) T cells depend on HIF-2 alpha activity in healthy and pathologic livers

Jong Hoon Kim, Ji Won Han, Young Joon Choi, Min-Seok Rha, June Young Koh, Kyung Hwan Kim, Chang Gon Kim, Yong Joon Lee, A Reum Kim, Junsik Park, Hong Kwan Kim, Byung Soh Min, Seong Il Seo, Minyong Kang, Hye Jung Park, Dai Hoon Han, Soon Il Kim, Myoung Soo Kim, Jae Geun Lee, Dong Hyeon Lee, Won Kim, Jun Yong Park, Su-Hyung Park*, Dong Jin Joo*, Eui-Cheol Shin* [JOURNAL OF HEPATOLOGY 72:6, 1170-1181(2020)]

CD69(+)CD103(-)CD8(+) T cell, HIF-2α, Human liver, Terminal differentiation, Tissue residency

Baseline Serum Interleukin-6 Levels Predict the Response of Patients with Advanced Non-small Cell Lung Cancer to PD-1/PD-L1 Inhibitors

Da Hyun Kang, Cheol-Kyu Park, Chaeuk Chung, In-Jae Oh, Young-Chul Kim, Dongil Park, Jinhyun Kim, Gye Cheol Kwon, Insun Kwon, Pureum Sun, Eui-Cheol Shin, Jeong Eun Lee* [IMMUNE NETWORK 20:3(2020)]

IL-6, Immunological antineoplastic agents, Lung cancer, PD-1/PD-L1