Center for
Genomic Integrity

Tardigrades: Trained to be hardy in the face of DNA damage

Stéphane G.M. Rolland, Nadin Memar, Anton Gartner [Current Biology   34, 10, R504-R507(2024) ]

RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

Son Mi Young, Belan Ondrej, Spirek Mario, Cibulka Jakub, Nikulenkov Fedor, You Young Kim, Sunyoung Hwang, Kyungjae Myung, Montagna Cristina, Tae Moon Kim, Krejci Lumir, Hasty Paul [iScience   27, 4(2024) ]

XPA tumor variant leads to defects in NER that sensitize cells to cisplatin

Blee Alexandra M, Gallagher Kaitlyn S, Hyun-Suk Kim, Mihyun Kim, Kharat Suhas S, Troll Christina R, D&apos,Souza Areetha, Jiyoung Park, Neufer P Drew, Orlando D Schärer, Chazin Walter J [NAR Cancer   6, 1(2024) ]

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

Saredi Giulia, Carelli Francesco N., Stephane G. M. Rolland, Furlan Giulia, Piquet Sandra, Appert Alex, Sanchez-Pulido Luis, Price Jonathan L., Alcon Pablo, Lampersberger Lisa, Declais Anne-Cecile, Ramakrishna Navin B., Toth Rachel, Macartney Thomas, Alabert Constance, Ponting Chris P., Polo Sophie E., Miska Eric A., Anton Gartner, Ahringer Julie, Rouse John [Nature Structural & Molecular Biology   31, 3, 523-535(2024) ]

Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes

Kook Son, Takhaveev Vakil, Visesato Mor, Hobin Yu, Dillier Emma, Zilio Nicola, Püllen Nikolai J. L., Dmitri Ivanov, Ulrich Helle D., Sturla Shana J., Orlando D. Schärer [Nature Communications   15, 1(2024) ]

Highly efficient genome editing via CRISPR-Cas9 ribonucleoprotein (RNP) delivery in mesenchymal stem cells

Han A Reum, Ha Rim Shin, Kwon Jiyeon, Lee Soo Been, Lee Sang Eun, Kim Eun-Young, Kweon Jiyeon, Chang Eun-Ju, Kim Yongsub, Kim Seong Who [BMB Reports   57, 1, 60-65(2024) ]

Detection of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy

Slyskova Jana, Muniesa-Vargas Alba, Da Silva Israel Tojal, Drummond Rodrigo, Jiyeong Park, Häckes David, Poetsch Isabella, Ribeiro-Silva Cristina, Moretton Amandine, Heffeter Petra, Orlando D Schärer, Vermeulen Wim, Lans Hannes, Loizou Joanna I [NAR Cancer   5, 4(2023) ]

Convergent differentiation of multiciliated cells

Chae Shinhyeok, Tae Joo Park, Taejoon Kwon [Scientific Reports   13, 1(2023) ]