Korea VirusResearch Institute

Spatial immune heterogeneity of hypoxia-induced exhausted features in high-grade glioma

A-Reum Kim, Seong Jin Choi, Junsik Park, Minsuk Kwon, Tamrin Chowdhury, Hyeon Jong Yu, Sojin Kim, Ho Kang, Kyung-Min Kim, Su-Hyung Park, Chul-Kee Park*, Eui-Cheol Shin* [OncoImmunology 11:1(2022)]

High-grade glioma, T cell, hypoxia, immune cell, tumor microenvironment

Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmission

Young-Il Kim, Se-Mi Kim, Su-Jin Park, Eun-Ha Kim, Kwang-Min Yu, Jae-Hyung Chang, Eun Ji Kim, Mark Anthony B Casel, Rare Rollon, Seung-Gyu Jang, Jihye Um, Min-Suk Song, Hye Won Jeong, Eung-Gook Kim, Yeonjae Kim, So Yeon Kim, Jun-Sun Park, Mi Sun Park, Geun-Yong Kwon, Sang Gu Yeo, Shin-Ae Lee, Youn Jung Choi, Jae U Jung, Young Ki Choi* [Emerging Microbes and Infections 10:1, 152-160(2021)]

COVID-19, SARS-CoV-2, ferret model, neutralizing antibody, reinfection

Development of a rapid fluorescent diagnostic system to detect subtype h9 influenza a virus in chicken feces

Hien Thi Tuong, Ju Hwan Jeong, Young Ki Choi, Hyun Park, Yun Hee Baek*, Seon-Ju Yeo* [International Journal of Molecular Sciences 22:16(2021)]

fecal specimen, monoclonal antibody, rapid fluorescent immunochromatographic test, subtype H9 influenza A virus

Absolute quantification of tumor-infiltrating immune cells in high-grade glioma identifies prognostic and radiomics values

A Reum Kim, Kyu Sung Choi, Min-Sung Kim, Kyung-Min Kim, Ho Kang, Sojin Kim, Tamrin Chowdhury, Hyeon Jong Yu, Chae Eun Lee, Joo Ho Lee, Soon-Tae Lee, Jae Kyung Won, Jin Wook Kim, Yong-Hwy Kim, Tae Min Kim, Sung-Hye Park, Seung Hong Choi*, Eui-Cheol Shin*, Chul-Kee Park* [CANCER IMMUNOLOGY IMMUNOTHERAPY 70:7, 1955-2008(2021)]

High-grade glioma, Quantification, Radiomics, Tumor-associated macrophage, Tumor-infiltrating lymphocyte

Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets

Jeong Seok Lee*, June-Young Koh, Kijong Yi, Young-Il Kim, Su-Jin Park, Eun-Ha Kim, Se-Mi Kim, Sung Ho Park, Young Seok Ju, Young Ki Choi*, Su-Hyung Park* [Nature Communications 12:1(2021)]

Monocytes and macrophages, SARS-CoV-2, Viral infection

Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome

Angela Park, Su-Jin Park, Kyle L Jung, Se Mi Kim, Eun-Ha Kim, Young-Il Kim, Suan-Sin Foo, Sunghyun Kim, Seong-Gyu Kim, Kwang-Min Yu, Younho Choi, Ji Yeun Kim, Yun Hee Baek, Min-Suk Song, Seung Ryul Kim, Seok-Yong Kim, Hye Won Jeong, Sung-Han Kim, Jae U Jung*, Young Ki Choi* [MBIO 12:1(2021)]

SFTS, SFTSV, bandavirus, emerging virus, immunoprofiling, plasma B cell, proximity extension assay, single-cell RNA-seq

PD-1 blockade-unresponsive human tumor-infiltrating CD8(+) T cells are marked by loss of CD28 expression and rescued by IL-151

Kyung Hwan Kim, Hong Kwan Kim, Hyung-Don Kim, Chang Gon Kim, Hoyoung Lee, Ji Won Han, Seong Jin Choi, Seongju Jeong, Minwoo Jeon, Hyunglae Kim, Jiae Koh, Bo Mi Ku, Su-Hyung Park, Myung-Ju Ahn*, Eui-Cheol Shin* [Cellular and Molecular Immunology 18:2, 385-397(2021)]

CD28, IL-15, T cells, TCF1, anti-PD-1

TOX-expressing terminally exhausted tumor-infiltrating CD8(+) T cells are reinvigorated by co-blockade of PD-1 and TIGIT in bladder cancer

Hye Sook Han, Seongju Jeong, Hyunglae Kim, Hyung-Don Kim, A Reum Kim, Minsuk Kwon, Su-Hyung Park, Chang Gok Woo, Hee Kyung Kim, Ki Hyeong Lee, Sung Pil Seo, Ho Won Kang, Won Tae Kim, Wun-Jae Kim, Seok Joong Yun*, Eui-Cheol Shin* [CANCER LETTERS 499, 137-147(2021)]

Bladder cancer, CD8(+) T cell, PD-1, TIGIT, TOX