Center for
Genomic Integrity

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Elizabeth L. Thompson, Jung E.Yeo, Eun-A Lee, Yinan Kan, Maya Raghunandan, Constanze Wiek, Helmut Hanenberg, Orlando D. Schärer, Eric A. Hendrickson, Alexandra Sobeck [Nucleic Acids Research   45, 20, 11837-11857(2017) ]

Nucleosomes influence multiple steps during replication initiation

Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A Belsky, David M. MacAlpine, Craig L. Peterson, Stephen P. Bell [Elife   6, e22512(2017) ]

Crystal Structures of Mmm1 and Mdm12-Mmm1 Reveal Mechanistic Insight into Phospholipid Trafficking at ER-Mitochondria Contact Sites

Hanbin Jeong, Jumi Park, Youngsoo Jun, Changwook Lee [Proceedings of the National Academy of Sciences of the United States of America   114, 45, E9502-E9511(2017) ]

Mutagenicity of a model DNA-peptide crosslink in human cells: Roles of translesion synthesis polymerases

Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK [Chem Res Tox   30(2), 669-677(2017) ]

A new sub-pathway of long-patch base excision repair involving 5` gap formation

Woodrick JA, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatakar P, Erzikan HV, Sami, F, Su Y, Schärer OD, Sharma S, Roy R [EMBO J   36(11), 1605-1622(2017) ]

Drosophila DNA Polymerase Theta Utilizes both Helicase-Like and Polymerase Domains during Microhomology-Mediated End Joining and Interstrand Crosslink Repair

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, McVey M [PLoS Genetics   13, 5, e1006813, e1006813-(2017) ]

ERCC1-XPF endonuclease – positioned to cut

Schärer, O.D. [EMBO J   36(14), 1993-1955(2017) ]

SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner

Deokjae Lee, Jungeun An, Young-Un Park, Hungjiun Liaw, Roger Woodgate, Jun Hong Park, and Kyungjae Myung [Proceedings of the National Academy of Sciences of the United States of America   114, 17, E3424-E3433(2017) ]