Center for
Genomic Integrity

Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J [Cell Reports   21, 5, 1375-1385(2017) ]

FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Elizabeth L. Thompson, Jung E.Yeo, Eun-A Lee, Yinan Kan, Maya Raghunandan, Constanze Wiek, Helmut Hanenberg, Orlando D. Schärer, Eric A. Hendrickson, Alexandra Sobeck [Nucleic Acids Research   45, 20, 11837-11857(2017) ]

Nucleosomes influence multiple steps during replication initiation

Ishara F. Azmi, Shinya Watanabe, Michael F. Maloney, Sukhyun Kang, Jason A Belsky, David M. MacAlpine, Craig L. Peterson, Stephen P. Bell [Elife   6, e22512(2017) ]

Crystal Structures of Mmm1 and Mdm12-Mmm1 Reveal Mechanistic Insight into Phospholipid Trafficking at ER-Mitochondria Contact Sites

Hanbin Jeong, Jumi Park, Youngsoo Jun, Changwook Lee [Proceedings of the National Academy of Sciences of the United States of America   114, 45, E9502-E9511(2017) ]

Mutagenicity of a model DNA-peptide crosslink in human cells: Roles of translesion synthesis polymerases

Pande P, Ji S, Mukherjee S, Schärer OD, Tretyakova NY, Basu AK [Chem Res Tox   30(2), 669-677(2017) ]

A new sub-pathway of long-patch base excision repair involving 5` gap formation

Woodrick JA, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatakar P, Erzikan HV, Sami, F, Su Y, Schärer OD, Sharma S, Roy R [EMBO J   36(11), 1605-1622(2017) ]

Drosophila DNA Polymerase Theta Utilizes both Helicase-Like and Polymerase Domains during Microhomology-Mediated End Joining and Interstrand Crosslink Repair

Beagan K, Armstrong RL, Witsell A, Roy U, Renedo N, Baker AE, Schärer OD, McVey M [PLoS Genetics   13, 5, e1006813, e1006813-(2017) ]

ERCC1-XPF endonuclease – positioned to cut

Schärer, O.D. [EMBO J   36(14), 1993-1955(2017) ]