Center for
Genomic Integrity

High-throughput single-molecule imaging system using nanofabricated trenches and fluorescent DNA-binding proteins

Yujin Kang, Na Young Cheon, Jongjin Cha, Ayoung Kim, Hyung-il Kim, Luda Lee, Kang O. Kim, Kyubong Jo, Ja Yil Lee [Biotechnology and Bioenineering   117, 6, 1640-1648(2020) ]

Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis

EXPERIMENTAL AND MOLECULAR MEDICINE Sun Sil Choi, Sang Kwon Lee, Joong Kwan Kim, Hye-Kyung Park, Eujin Lee, Jinho Jang, Yo Han Lee, Keon Woo Khim, Ji-Min Hyun, Hye-jin Eom, Semin Lee, Byuong Heon Kang, Young Chan Chae, Kyungjae Myung, Seung-Jae Myung, Chan Young Park, Jang Hyun Choi [Experimenal and Molecular Medicine   52, 6, 940-950(2020) ]

Mutational signatures are jointly shaped by DNA damage and repair

Volkova N.V., Meier B., Gonzalez-Huici V., Bertolini S., Gonzalez S., Vohringer H., Abascal F., Martincorena I., Campbell P.J., Anton Gartner, Gerstung M. [Nature Communications   11, 1, 2169(2020) ]

Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin

Ming X., Michaelson-Richie E.D., Arnold S. Groehler IV, Villalta P.W., Campbell C., Tretyakova N.Y. [DNA REPAIR   89, 102840(2020) ]

Structural basis of the fanconi anemia-associated mutations within the FANCA and FANCG complex

Eunyoung Jeong, Seong-Gyu Lee, Hyun-Suk Kim, Jihyeon Yang, Jinwoo Shin, Youngran Kim, Jihan Kim, Orlando D Schärer, Youngjin Kim, Jung-Eun Yeo, Ho Min Kim, Yunje Cho [Nucleic Acids Research   48, 6, 3328-3342(2020) ]

Alpha-tocopherol exerts protective function against the mucotoxicity of particulate matter in amphibian and human goblet cells

Hee-Sun Yang, Hyo Jung Sim, Hanna Cho, Woo Young Bang, Ha Eun Kim, Taeg Kyu Kwon, Taejoon Kwon, Tae Joo Park [Scientific Reports   10, 1, 6224(2020) ]

The C-terminal tail of the yeast mitochondrial transcription factor Mtf1 coordinates template strand alignment, DNA scrunching and timely transition into elongation

Urmimala Basu, Seung-Won Lee, Aishwarya Deshpande, Jiayu Shen, Byeong-Kwon Sohn, Hayoon Cho, Hajin Kim, Smita S Patel [Nucleic Acids Research   48, 5, 2604-2620(2020) ]

A key interaction with RPA orients XPA in NER complexes

Topolska-Wos A.M., Sugitani N., Cordoba J.J., Le Meur K.V., Le Meur R.A., Hyun Suk Kim, Jung-Eun Yeo, Rosenberg D., Hammel M., Orlando D. Sch¨arer, Chazin W.J. [Nucleic Acids Research   48, 4, 2173-2188(2020) ]