Korea VirusResearch Institute

Immune checkpoint inhibitor-induced reinvigoration of tumor-infiltrating CD8+ T cells is determined by their differentiation status in glioblastoma

Junsik Park, Minsuk Kwon, Kyung Hwan Kim, Tae-Shin Kim, Seon-Hui Hong, Chang Gon Kim, Seok-Gu Kang, Ju Hyung Moon, Eui Hyun Kim, Su-Hyung Park, Jong Hee Chang, Eui-Cheol Shin* [Clinical Cancer Research 25:8, 2549-2559(2019)]

tumor-infiltrating, CD8(+) T cells

The first-week proliferative response of peripheral blood PD-1þCD8þ T cells predicts the response to Anti-PD-1 therapy in solid tumors

Kyung Hwan Kim, Jinhyun Cho, Bo Mi Ku, Jiae Koh, Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn, Jaekyung Cheon, Young Joo Min, Su-Hyung Park, Keunchil Park, Myung-Ju Ahn*, Eui-Cheol Shin [Clinical Cancer Research 25:7, 2144-2154(2019)]

Anti-PD-1, solid tumor

Sustained type I interferon reinforces NK cell–mediated cancer immunosurveillance during chronic virus infection

Ji Hoon Oh, Myeong Joon Kim, Seong Jin Choi, Young Ho Ban, Heung Kyu Lee, Eui-Cheol Shin, Kyung-Mi Lee*, Sang-Jun Ha [Cancer Immunology Research 7:4, 584-599(2019)]

NK cell, virus infection

Ferret animal model of severe fever with thrombocytopenia syndrome phlebovirus for human lethal infection and pathogenesis

Su-Jin Park, Young-Il Kim, Angela Park, Hyeok-Il Kwon, Eun-Ha Kim, Young-Jae Si, Min-Suk Song, Chul-Ho Lee, Kyle Jung, Woo-Jin Shin, Jianxiong Zeng, Younho Choi, Jae U Jung*, Young Ki Choi* [NATURE MICROBIOLOGY 4:3, 438-446(2019)]

Applied microbiology, Viral pathogenesis, Virology

Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis

Younho Choi, Su-Jin Park, Yinyan Sun, Ji-Seung Yoo, Raghavendra Sumanth Pudupakam, Suan-Sin Foo, Woo-Jin Shin, Sally B Chen, Philip N Tsichlis, Won-Ja Lee, Jong-Soo Lee, Wenhui Li, Benjamin Brennan, Young-Ki Choi, Jae U Jung* [NATURE MICROBIOLOGY 4:3, 429-437(2019)]

Innate immunity, Viral infection, Viral pathogenesis

In Vitro and In Vivo Characterization of Novel Neuraminidase Substitutions in Influenza A(H1N1) pdm09 Virus Identified Using Laninamivir-Mediated In Vitro Selection

Khristine Kaith S Lloren, Jin Jung Kwon, Won-Suk Choi, Ju Hwan Jeong, Su Jeong Ahn, Young Ki Choi, Yun Hee Baek*, Min-Suk Song* [JOURNAL OF VIROLOGY 93:6(2019)]

influenza A virus, laninamivir, neuraminidase, pandemic H1N1 virus, resistance, viral fitness

Tumor necrosis factor and regulatory T cells

Min Kyung Jung, Jeong Seok Lee, Jeong Eun Kwak, Eui Cheol Shin* [Yonsei Medical Journal 60:2, 126-131(2019)]

TNFR2, Tumor necrosis factor, inflammation, regulatory T cell

Editorial: Stress and immunity

Yong-Soo Bae, Eui-Cheol Shin, Yoe-Sik Bae, Willem Van Eden* [Frontiers in Immunology 10:245(2019)]

cell stress, heat shock (stress) proteins, psychological stress, stress protein, unfolded protein response (UPR)