Korea VirusResearch Institute

Molecular identification of severe fever with thrombocytopenia syndrome virus in deer ked: Implications for disease transmission

Mark Anthony B Casel, Jeong Ho Choi, Hyunwoo Jang, Seung-Gyu Jang, Juryeon Gil, Rare Rollon, So-Youn Cheun, Isaac Choi, Eun-Ha Kim, Young-Il Kim, Young Ki Choi [One Health 21(2025)]

Deer ked; Lipoptena fortisetosa; SFTSV

TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells

Hoyoung Lee, So-Young Kim, Sang-Hoon Kim, Seongju Jeong, Kyung Hwan Kim, Chang Gon Kim, June-Young Koh, Hyung-Don Kim, Ji Won Han, Hosun Yu, Wonyong Lee, Sunwoo Min, Su-Hyung Park, Hyuk Soo Eun, Eui-Cheol Shin [Immunity 58(12), 2957-2971(2025)]

Ca(2+)–calcineurin signaling; IL-15; NFATc1; TCR; bystander activation.

AIM2 drives inflammatory cell death and monkeypox pathogenesis

Jueun Oh#, Yun-Ho Hwang#, Jihye Lee#, Cheong Seok#, SuHyeon Oh, Hye Yoon Kim, Nabukenya Mariam, Jaeyoung Ahn, GyeongJu Yu, Jaewoo Park, Hayeon Kim, Suhyun Kim, Seyun Shin, Min-Chul Jung, Jinwoo Gil, Joo Sang Lee, Young Ki Choi, Dokeun Kim, Daesik Kim, You-Jin Kim, SangJoon Lee [cellular & molecular immunology 22(12), 1615-1628(2025)]

AIM2; Inflammasome; Inflammation; Inflammatory cell death; Innate immunity; Monkeypox virus.

A SARS-CoV-2 Mpro mutation conferring ensitrelvir resistance paradoxically increases nirmatrelvir susceptibility

Seong Cheol Min#, Jin-Ju Seo#, Ju Hwan Jeong, Beom Kyu Kim, Ji-Hyun Park, Ju Ryeong Lee, Dong Gyu Lee, Gi Chan Lee, Se Hee An, Yun Hee Baek, Young Ki Choi, Hyunah Choo, Hyo Yong Park, Gyeongmin Kim, Byungsun Jeon, Sang Chul Shin, Min-Suk Song [Nature Communications 16(1)(2025)]

Therapeutic applications of interface-mimicking peptides for targeting the SARS-CoV-2 NSP12-NSP8 RdRp complex

Mark Anthony B. Casel, Jae-Woo Ahn, Hyunjoon Kim, Isaac Choi, Seung-Gyu Jang, Rare Rollon, Ho-Young Ji, Mina Yu, Seong Cheol Min, Min-Suk Song, Young Ki Choi [Molecular Therapy 33(9), 4471-4487(2025)]

NSP12-NSP8 interface; NSP8-based peptides; RdRp complex; SARS-CoV2; antiviral peptides.

Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses

Yeon Jeong Yoo#, Suhyeon Kim#, Asha Wickramasinghe#, Jaemoo Kim#, JuA Song, Young-Il Kim, Juryeon Gil, Young-Woock Noh, Min-Ho Lee, Sang-Seok Oh, Myeong-Mi Lee, Yebin Seong, Jong-Soo Lee, Young Ki Choi, Yong Taik Lim [Cellular & Molecular Immunology 22(9), 1045-1060(2025)]

Dynamic immunomodulation; Heterologous viruses; Nanoemulsion; TLR7/8 agonist; Vaccine adjuvant.

Prolonged immune activation in post-acute sequelae of SARS-CoV-2: neutrophil dynamics and therapeutic insights

Mina Yu#, Suhee Hwang#, Hobin Jang#, Dongbin Park, Jaemoo Kim, Juryeon Gil, Jeong Ho Choi, Seung-Gyu Jang, Isaac Choi, Yuri Jung, Woohyun Kwon, Se-Mi Kim, Young-Il Kim, Hyunjoon Kim, Taehwan Oh, Joo Sang Lee, Min-Suk Song, SangJoon Lee, Young Ki Choi [Experimental & Molecular Medicine 57(9), 2067-2082(2025)]

PB2 and NP of North American H5N1 virus drive immune cell replication and systemic infections

Young-Il Kim, Seung-Gyu Jang, Woohyun Kwon, Jaemoo Kim, Dongbin Park, Isaac Choi, Jeong Ho Choi, Juryeon Gil, Mina Yu, Boyeong Jeong, Eun-Ha Kim, Se-Mi Kim, Hyunjoon Kim, Jae-Woo Ahn, Suhee Hwang, Seo-Young Heo, Mark Anthony B Casel, Rare Rollon, Thomas Fabrizio, Richard J Webby, Young Ki Choi [Science Advances 11(39)(2025)]