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Chief Investigator

CI. Ho Min Kim

Dr. Ho Min Kim joined the Graduate School of Medical science & Engineering (GSMSE), KAIST in 2011 and established the “Disease Molecule Biochemistry Lab”. Using structural biology techniques (X-ray Crystallography and Cryo-EM) as well as biochemical and cell-biological approaches, he has been investigated the molecular mechanisms of various protein complexes which play a critical role in human pathophysiology such as immune response and synaptogenesis. In parallel, based on the structure of disease-related protein complexes, he designed new therapeutic hybrid proteins and further develop them as potential biologics for cancer treatment.

In December, 2018, he has appointed as a chief investigator and launched the Protein Communication group (Center for biomolecular and cellular structure) at IBS Headquarter.

Educations

1995-1999
B.S., KAIST, Department of Biological Science
1999-2001
M.S., KAIST, Department of Biological Science
2001-2005
Ph.D., KAIST, Department of Biological Science

Research and Professional Careers

2005-2006
Postdoctoral Fellow (Prof. Ook Joon, Yoo) Biomedical Research Center, KAIST
2006-2007
Postdoctoral Fellow (Prof. Jie-oh, Lee), Department of Chemistry, KAIST
2007-2011
Postdoctoral Fellow (Prof. Yifan, Cheng), Department of Biophysics and Biochemistry, University of California San Francisco
2011-2015
Assistant Professor, GSMSE, KAIST
2016-Present
Associate Professor, GSMSE, KAIST
2011-Present
Adjunct Professor, KI for Biocentury, KAIST
2014-Present
Adjunct Professor, Department of Biological Science, KAIST
2018-Present
Chief Investigator, Center for biomolecular & Cellular Structure (Protein Communication Group), IBS

Major Publications

● Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell, 2007 Sep 7; 130(5):906-17.
● Reconfiguration of the proteasome during chaperone-mediated assembly. Nature, 2013 May 23; 497(7450):512-6.
● Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion. Nature Communications. 2014 Nov 14;5:5423.
● Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer. Immunity. 2017 Jan 17;46(1):38-50.
● Structural Insights into Modulation of Neurexin-Neuroligin Trans-synaptic Adhesion by MDGA1/Neuroligin-2 Complex. Neuron. 2017 Jun 21; 94(6): 1121-1131, Issue Highlights.
● Multi-paratopic VEGF decoy receptor have superior anti-tumor effects through anti-EGFRs and targeted anti-angiogenic activities. Biomaterials. 2018 Apr 16;171:34-45.
● Four-fold Channel-Nicked Human Ferritin Nanocages for Active Drug Loading and pH-Responsive Drug Release. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2909-2913.

Honors and Awards

● Young Scientist Award, Ministry of Science and Technology, Republic of Korea, 2007.
● Agarwal Award, BMRC, KAIST, Republic of Korea, 2009.
● Ewon Assistant Professor, KAIST, Republic of Korea, 2015.
● Award for Academic Excellence, KAIST, Republic of Korea, 2017.
● KAIST Top 10 Representative Researches Award, KAIST, 2017.
● Asan Award in Medicine for Young Medical Scientists, Asan Foundation, 2018.
● National R&D Excellence 100, Minister of Science and ICT, Republic of Korea, 2018.

Research Interests

● Structure of Disease related-protein complex & Leucine-Rich Repeat (LRR) containing Protein
● Structure-based Protein Engineering
● Cryo-EM, X-ray Crystallography

Center for Biomolecular and Cellular Structure
(Protein Communication Group)

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