Korea VirusResearch Institute

Peptide Nucleic Acid (PNA)-Enhanced Specificity of a Dual-Target Real-Time Quantitative Polymerase Chain Reaction (RT-qPCR) Assay for the Detection and Differentiation of SARS-CoV-2 from Related Viruses

Won-Suk Choi, Ju Hwan Jeong, Halcyon Dawn G Nicolas, Sol Oh, Khristine Joy C Antigua, Ji-Hyun Park, Beomkyu Kim, Sun-Woo Yoon, Kyeong Seob Shin, Young Ki Choi, Yun Hee Baek*, Min-Suk Song* [DIAGNOSTICS 10:10(2020)]

PNA, RT-qPCR, SARS related-CoV, SARS-CoV-2, dual-target detection

Human liver CD8(+) MAIT cells exert TCR/MR1-independent innate-like cytotoxicity in response to IL-15

Min-Seok Rha, Ji Won Han, Jong Hoon Kim, June-Young Koh, Hye Jung Park, Soon Il Kim, Myoung Soo Kim, Jae Geun Lee, Hyun Woong Lee, Dong Hyeon Lee, Won Kim, Jun Yong Park, Dong Jin Joo*, Su-Hyung Park*, Eui-Cheol Shin* [JOURNAL OF HEPATOLOGY 73:3, 640-650(2020)]

Cytotoxicity, Hepatitis, IL-15, Mucosal-associated invariant T cells, Virus

Distinct tumor immune microenvironments in primary and metastatic lesions in gastric cancer patients

Seung-Myoung Son, Chang Gok Woo, Dae Hoon Kim, Hyo Yung Yun, Hongsik Kim, Hee Kyung Kim, Yaewon Yang, Jihyun Kwon, Minsuk Kwon, Tae-Yong Kim, Hyung-Don Kim, June-Young Koh, Su-Hyung Park, Eui-Cheol Shin*, Hye Sook Han* [SCIENTIFIC REPORTS 10:1(2020)]

Cancer, Immunology, Oncology

Effects of Cryopreservation and Thawing on Single-Cell Transcriptomes of Human T Cells

Jeong Seok Lee, Kijong Yi, Young Seok Ju, Eui-Cheol Shin* [IMMUNE NETWORK 20:4(2020)]

Cryopreservation, Single-cell analysis, T-lymphocytes, regulatory, Transcriptome

Single-cell RNA sequencing identifies shared differentiation paths of mouse thymic innate T cells

Minji Lee, Eunmin Lee, Seong Kyu Han, Yoon Ha Choi, Dong-Il Kwon, Hyobeen Choi, Kwanghwan Lee, Eun Seo Park, Min-Seok Rha, Dong Jin Joo, Eui-Cheol Shin, Sanguk Kim*, Jong Kyoung Kim*, You Jeong Lee* [NATURE COMMUNICATIONS 11:1(2020)]

Gammadelta T cells, Innate lymphoid cells, NKT cells, Thymus

Early reduction of regulatory T cells is associated with acute rejection in liver transplantation under tacrolimus-based immunosuppression with basiliximab induction

Ji Won Han, Dong Jin Joo, Jong Hoon Kim, Min-Seok Rha, June Young Koh, Hye Jung Park, Jae Geun Lee, Myoung Soo Kim, Soon Il Kim, Eui-Cheol Shin, Jun Yong Park*, Su-Hyung Park* [American Journal of Transplantation 20:8, 2058-2069(2020)]

immunobiology, immunosuppressant - calcineurin inhibitor (CNI), immunosuppression/immune modulation, liver transplantation/hepatology, lymphocyte biology, rejection, acute, translational research/science

Inducing Transient Mixed Chimerism for Allograft Survival Without Maintenance Immunosuppression With Combined Kidney and Bone Marrow Transplantation: Protocol Optimization

Kyo Won Lee, Jae Berm Park*, Hyojun Park, Yeongbeen Kwon, Ji Soo Lee, Kyeong Sik Kim, Young Jae Chung, Jin Soo Rhu, Sooin Choi, Ghee Young Kwon, Hee Jin Kim, Eun-Suk Kang, Chul Won Jung, Eui-Cheol Shin, Tatsuo Kawai, Sung Joo Kim, Jae-Won Joh [TRANSPLANTATION 104:7, 1472-1482(2020)]

Maintenance Immunosuppression

Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19

Jeong Seok Lee, Seongwan Park, Hye Won Jeong, Jin Young Ahn, Seong Jin Choi, Hoyoung Lee, Baekgyu Choi, Su Kyung Nam, Moa Sa, Ji-Soo Kwon, Su Jin Jeong, Heung Kyu Lee, Sung Ho Park, Su-Hyung Park, Jun Yong Choi*, Sung-Han Kim*, Inkyung Jung*, Eui-Cheol Shin* [SCIENCE IMMUNOLOGY 5:49(2020)]

COVID-19, influenza