Korea VirusResearch Institute

HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

Jang, Seung-Gyu; Young-Il Kim; Casel, Mark Anthony B.; Choi, Jeong Ho; Gil, Ju Ryeon; Rollon, Rare; Eun-Ha Kim; Se-Mi Kim; Ho Young Ji; Dong Bin Park; Hwang, Jungwon; Jae-Woo Ahn; Kim, Myung Hee; Min-Suk Song; Young Ki Choi [Emerging Microbes & Infections 13(1)(2024)]

HPAI H5N8 virus, Clade 2.3.4.4, reassortant, pathogenecity, South Korea

SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility

Se-Mi Kim; Eun-Ha Kim; Casel, Mark Anthony B.; Young-Il Kim; Sun, Rong; Kwak, Mi-Jeong; Ji-Seung Yoo; Mina Yu; Yu, Kwang-Min; Jang, Seung-Gyu; Rollon, Rare; Choi, Jeong Ho; Gil, Juryeon; Eun, Kiyoung; Kim, Hyunggee; Ensser, Armin; Hwang, Jungwon; Song, Min-Suk; Kim, Myung Hee; Jung, Jae U.; Young Ki Choi [Cell Reports 42(9)(2023)]

Emerging Tick-Borne Dabie bandavirus: Virology, Epidemiology, and Prevention

Eun-Ha Kim; Park, Su-Jin [Microorganisms 11(9)(2023)]

Evaluating Z-FA-FMK, a host cathepsin L protease inhibitor, as a potent and broad-spectrum antiviral therapy against SARS-CoV-2 and related coronaviruses

Jeong, Ju Hwan; Choi, Jang-Hoon; Kim, Beom Kyu; Min, Seong Cheol; Chokkakula, Santosh; Oh, Sol; Park, Ji-Hyun; Shim, Sang-Mu; Kim, Eung-Gook; Young Ki Choi; Lee, Joo-Yeon; Baek, Yun Hee; Song, Min-Suk [Antiviral Research 216(2023)]

A Rapid Method for Generating Infectious SARS-CoV-2 and Variants Using Mutagenesis and Circular Polymerase Extension Cloning

Kim, Beom Kyu; Choi, Won-Suk; Jeong, Ju Hwan; Oh, Sol; Park, Ji-Hyun; Yun, Yu Soo; Min, Seong Cheol; Kang, Da Hyeon; Kim, Eung-Gook; Ryu, Hojin; Kim, Hye Kwon; Baek, Yun Hee; Choi, Young Ki; Song, Min-Suk [Microbiology spectrum 11(2)(2023)]

Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets

Dokyun Kim, Eunha Kim, Semi Kim, Youseung Chung, Sung-Dong Cho, Yunseo Choi, Chih-Jen Lai, Xinghong Dai, Seokmin Kang, Mi-Jeong Kwak, Inho Cha, Ziyi Liu , Younho Choi , Su-Hyung Park , Young Ki Choi , Jae U Jung [American Society for Microbiology v.14(5)(2023)]

Dabie bandavirus, nanoparticle, tick-borne pathogens, vaccine, ferret model

Development of a Universal Cloning System for Reverse Genetics of Human Enteroviruses

Won-Suk Choi, Sol Oh, Khristine Joy C. Antigua, Ju Hwan Jeong, Beom Kyu Kim, Yu Soo Yun, Da Hyeon Kang, Seong Cheol Min, Byung-Kwan Lim, Won Seop Kim, Ji-Hyuk Lee, Eung-Gook Kim, Young Ki Choi, Yun Hee Baek, Min-Suk Song* [Microbiology Spectrum 11:1(2023)]

Human Enteroviruses, whole-genome cDNA template, universal cloning system

Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected mice

Ju Hwan Jeong, Santosh Chokkakula, Seong Cheol Min, Beom Kyu Kim, Won-Suk Choi, Sol Oh, Yu Soo Yun, Da Hyeon Kang, Ok-Jun Lee, Eung-Gook Kim, Jang-Hoon Choi, Joo-Yeon Lee, Young Ki Choi, Yun Hee Baek, Min-Suk Song* [Antiviral Research 208(2022)]

SARS-CoV-2, Nirmatrelvir, Remdesivir, Molnupiravir, In vivo, Combination therapy