Korea VirusResearch Institute

The host protease KLK5 primes and activates spike proteins to promote human betacoronavirus replication and lung inflammation

Hyunjoon Kim; Yeonglim Kang; Semi Kim; Dongbin Park; Seo-Young Heo; Ji-Seung Yoo; Isaac Choi; N. Monford Paul Abishek; Jae-Woo Ahn; Yang, Jeong-Sun; Nayeon Bak; Kyeong Kyu; Lee, Joo-Yeon; Young Ki Choi [Science signaling 17(850)(2024)]

Evolutional dynamics of highly pathogenic avian influenza H5N8 genotypes in wintering bird habitats: Insights from South Korea`s 2020–2021 season

Si, Young Jae; Seung-gyu Jang; Young-Il Kim; Casel, Mark Anthony B.; Kim, Dong-ju; Ho Young Ji; Choi, Jeong Ho; Gil, Ju Ryeon; Rollon, Rare; Jang, Hyunwoo; Cheun, So Youn; Eun-Ha Kim; Jeong, Hyesung; Young Ki Choi [One Health 18(2024)]

HPAI H5N8, virusClade 2.3.4.4b, Reassortment, Genotypes, South Korea

Differential beta-coronavirus infection dynamics in human bronchial epithelial organoids

Dongbin Park; Se-Mi Kim; Hobin Jang; Kanghee Kim; Ho young Ji; Yang, Heedong; Woohyun Kwon; Yeonglim Kang; Suhee Hwang; Hyunjoon Kim; Mark Anthony B. Casel; Issac Choi; Yang, Jeong-Sun; Lee, Joo-Yeon; Young Ki Choi [Journal of Medical Virology 96(4)(2024)]

Mammalian adaptation risk in HPAI H5N8: a comprehensive model bridging experimental data with mathematical insights

Chokkakula, Santosh; Oh, Sol; Choi, Won-Suk; Kim, Chang Il; Jeong, Ju Hwan; Kim, Beom Kyu; Park, Ji-Hyun; Min, Seong Cheol; Kim, Eung-Gook; Baek, Yun Hee; Young Ki Choi; Song, Min-Suk [Emerging Microbes & Infections 13(1)(2024)]

HPAI H5N8, replication, adaptation, RNA load, regression, quantification, risk score

Inflammasome diversity: exploring novel frontiers in the innate immune response

Yu, Gyeongju; Young Ki Choi; Lee, SangJoon [Trends in Immunology 45(4), 248-258(2024)]

innate immunity, immune response, multiple inflammasome sensors, pathogen, infection, cytokines, inflammation, pyroptosis, apoptosis, necroptosis

HA N193D substitution in the HPAI H5N1 virus alters receptor binding affinity and enhances virulence in mammalian hosts

Jang, Seung-Gyu; Young-Il Kim; Casel, Mark Anthony B.; Choi, Jeong Ho; Gil, Ju Ryeon; Rollon, Rare; Eun-Ha Kim; Se-Mi Kim; Ho Young Ji; Dong Bin Park; Hwang, Jungwon; Jae-Woo Ahn; Kim, Myung Hee; Min-Suk Song; Young Ki Choi [Emerging Microbes & Infections 13(1)(2024)]

HPAI H5N8 virus, Clade 2.3.4.4, reassortant, pathogenecity, South Korea

SARS-CoV-2 variants with NSP12 P323L/G671S mutations display enhanced virus replication in ferret upper airways and higher transmissibility

Se-Mi Kim; Eun-Ha Kim; Casel, Mark Anthony B.; Young-Il Kim; Sun, Rong; Kwak, Mi-Jeong; Ji-Seung Yoo; Mina Yu; Yu, Kwang-Min; Jang, Seung-Gyu; Rollon, Rare; Choi, Jeong Ho; Gil, Juryeon; Eun, Kiyoung; Kim, Hyunggee; Ensser, Armin; Hwang, Jungwon; Song, Min-Suk; Kim, Myung Hee; Jung, Jae U.; Young Ki Choi [Cell Reports 42(9)(2023)]

Emerging Tick-Borne Dabie bandavirus: Virology, Epidemiology, and Prevention

Eun-Ha Kim; Park, Su-Jin [Microorganisms 11(9)(2023)]