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[Press Release] KVRI Research Published in Science,
IBS Korea Virus Research Institute and Center for Genome Engineering Develop Bat-Derived Organoids to Study Viral Infection and Immunity
A collaborative research team led by Director Young Ki Choi of the IBS Korea Virus Research Institute (KVRI) and Director Bum-Keun Ku of the IBS Center for Genome Engineering has successfully established long-term organoids derived from bats native to Korea. This platform enables the study of viral infection characteristics and immune responses in bat tissues.
The organoid biobank developed through this study is the largest of its kind in the world. It is expected to serve as both a standardized bat model and a critical platform for monitoring bat-derived emerging viruses and preparing for future pandemics.
https://www.science.org/doi/10.1126/science.adt1438
Abstract
Bats are important reservoirs of zoonotic pathogens, but suitable model systems for comprehensively exploring host-pathogen interactions and assessing spillover risks remain limited. To address this gap, we developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel showed species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and enteric zoonotic viruses. Using this platform, we successfully isolated and characterized bat-borne mammalian orthoreoviruses and paramyxoviruses, demonstrating the utility of these organoid panels for virome surveillance. Furthermore, we successfully tested known antiviral drugs for their efficacy against bat virus isolates.
1. Laboratory Footage (Research Sketch) : https://drive.google.com/file/d/1LAjupi6SH7SwG1ByIpMNJZqLGbBEYP0v/view?usp=sharing
2. Author Interviews
Prof. Young Ki Choi (Corresponding Author): https://drive.google.com/file/d/1nivAhZGLjO_byN6q7R-palDM-Xx8dYtb/view?usp=sharing
Prof. Bum-Keun Ku (Corresponding Author): https://drive.google.com/file/d/1z2m6Q4pldidZP9ZTUSXoSAq1Q5oWfVtP/view?usp=sharing
Dr. Hyun Joon Kim / Dr. Seo-Young Heo (First Authors): https://drive.google.com/file/d/1L_E9kENI0aluyp2WkrDtBmPI2_6mwYr3/view?usp=sharing
3. Time-Lapse Video of Virus-Infected Organoids: https://drive.google.com/file/d/1qItH5GA6wv_mEIsDbhXUracvnhczEPoQ/view?usp=sharing
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