RESEARCH TOPIC
We want to explore how epigenomic regulation determines brain cell
fate and function, and its relevance to neurological disorders. As the most abundant cell population in
our brain, the importance of astrocytes to maintain brain homeostasis is growing exponentially. However,
studies with chromatin regulation of astrocytes are still limited, due to the limitation of experimental
approaches and model systems. We propose to employ the hiPSC-derived model system with multi-omics
approaches (e.g., epigenomics, transcriptomics) to dissect underlying mechanisms of the astrocytic
identity and function. In the long run, our goal is to lay the foundation for potential biomedical
applications in the treatment of neurological disease.
Epigenomics, Astrocyte, hiPSC, Tripartite synapse,
Neural activity, Single-cell
RNA/ATAC-sequencing, Neurological disorder
[Professional experience]
2019 - 2022 | EIPOD Post-doctoral fellow in Genome Biology and Structural Biology Unit, EMBL, Germany |
2016 - 2018 | Post-doctoral fellow in Seoul National University, College of Medicine, Korea |
2009 - 2016 | Ph.D. in Unified Master's and Doctor's Course in Department of Biomedical Sciences, Seoul National University, College of Medicine, Korea |
[Honors and Awards]
(2021) The neurodevelopmental disorder-linked PHF14 complex that forms biomolecular condensates detects DNA damage and promotes repair, bioRxiv
(2021) Comparative chromatin accessibility upon BDNF-induced neuronal activity delineates neuronal regulatory elements, bioRxiv
(2018) Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation, Nucleic Acids Res
(2016) Psat1-Dependent Fluctuations in α-Ketoglutarate Affect the Timing of ESC Differentiation, Cell Metabolism